Developing a Clinically Relevant Hemorrhagic Shock Model in RatsThomas Dupas *1, Virginie Aillerie *1, Amandine Vergnaud 1, Thomas Pelé 1, Antoine Persello 1, Angélique Blangy-Letheule 1, Angélique Erraud 1, Mortéza Erfanian 1, Agnès Hivonnait 1, Anaïs Maillard 1, Jules Lecomte 2, Edith Bigot-Corbel 3, Aurélia A. Leroux 1,4, Manon Denis 2, Bertrand Rozec 2, Benjamin Lauzier 1
1CNRS, INSERM, l’institut du thorax, Nantes Université, 2CNRS, INSERM, l’institut du thorax, Nantes Université, CHU Nantes, 3Departement of Biochemistry, CHU de Nantes, 4Oniris
Hemorrhagic shock kills 1.9 million people worldwide every year. Small animals are frequently used as hemorrhagic shock models but are associated with issues of standardization, reproducibility, and clinical significance, thus limiting their relevance. This article describes developing a new clinically relevant hemorrhagic shock model in rats.
