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Lanzhou University

1 ARTICLES PUBLISHED IN JoVE

Chemistry

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Yani Zhou¹, Nannan Chen², Yaping Cheng², Xiaoqing Cai²

¹School of Basic Medical Sciences, Lanzhou University, ²School of Pharmaceutical Sciences, Sun Yat-sen University

Enantiomerically enriched bispiro[γ-butyrolactone-pyrrolidin-4,4'-pyrazolone] skeletons are asymmetrically synthesized through a simple organocatalytic 1,3-dipolar cycloaddition reaction.