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University at Buffalo, The State University of New York

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Mansik Jeon^1,2, Jeehyun Kim³, Chulhong Kim^1,2

¹Department of Biomedical Engineering, University at Buffalo, The State University of New York, ²Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH) , ³School of Electrical Engineering and Computer Science, Kyungpook National University

Photoacoustic cystography (PAC) has a great potential to map urinary bladders, a radiation sensitive internal organ in pediatric patients, without using any ionizing radiation or toxic contrast agent. Here we demonstrate the use of PAC for mapping urinary bladders with an injection of optical-opaque tracers in rats in vivo.

Bioengineering

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

Cheng S. Jin^1,2,3, Jonathan F. Lovell⁴, Gang Zheng^1,2,3

¹Department of Pharmaceutical Sciences, University of Toronto, ²The Institute of Biomaterials and Biomedical Engineering, University of Toronto, ³Ontario Cancer Institute, Campbell Family Institute For Cancer Research and Techna Institute, ⁴Department of Biomedical Engineering, University at Buffalo, The State University of New York

We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy in a xenograft tumor model.