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Soterix Medical

5 ARTICLES PUBLISHED IN JoVE

Medicine

Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Mauricio F. Villamar^1,2, Magdalena Sarah Volz^1,3, Marom Bikson⁴, Abhishek Datta^1,4, Alexandre F. DaSilva^*5, Felipe Fregni^*1

¹Laboratory of Neuromodulation, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, ²School of Medicine, Pontifical Catholic University of Ecuador, ³Charité University Medicine Berlin, ⁴The City College of The City University of New York, ⁵Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences, School of Dentistry, University of Michigan

High-definition transcranial direct current stimulation (HD-tDCS), with its 4x1-ring montage, is a noninvasive brain stimulation technique that combines both the neuromodulatory effects of conventional tDCS with increased focality. This article provides a systematic demonstration of the use of 4x1 HD-tDCS, and the considerations needed for safe and effective stimulation.

Medicine

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)

Margaret Kasschau^1,2, Kathleen Sherman^1,2, Lamia Haider², Ariana Frontario^1,2, Michael Shaw^1,2, Abhishek Datta³, Marom Bikson⁴, Leigh Charvet^1,2

¹Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Medical Center, ²Department of Neurology, Stony Brook Medicine, ³Soterix Medical, Inc, ⁴Department of Biomedical Engineering, The City College of New York

The goal of this pilot study is to describe a protocol for the remotely-supervised delivery of transcranial direct current stimulation (tDCS) so that the procedure maintains standards of in-clinic practice, including safety, reproducibility, and tolerability. The feasibility of this protocol was tested in participants with multiple sclerosis (MS).

Neuroscience

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Michael T. Shaw¹, Margaret Kasschau², Bryan Dobbs¹, Natalie Pawlak¹, William Pau¹, Kathleen Sherman¹, Marom Bikson³, Abhishek Datta⁴, Leigh E. Charvet¹

¹New York University, Langone Medical Center, ²Stony Brook Medicine, ³City College of New York, ⁴Soterix Medical

This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease.

Neuroscience

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Ingrid Rebello-Sanchez¹, Joao Parente¹, Kevin Pacheco-Barrios^1,2, Anna Marduy¹, Danielle Carolina Pimenta¹, Daniel Lima¹, Eric Slawka¹, Alejandra Cardenas-Rojas¹, Gleysson Rodrigues Rosa¹, Kamran Nazim³, Abhishek Datta^3,4, Felipe Fregni¹

¹Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, ²Universidad de Investigación para la Generación y Síntesis de Evidencia en Salud, Universidad San Ignacio de Loyola, ³Research and Development, Soterix Medical, ⁴City College of New York

Contralateral silent period (cSP) assessment is a promising biomarker to index cortical excitability and treatment response. We demonstrate a protocol to assess cSP intended for studying M1 corticospinal inhibition of upper and lower limbs.

Neuroscience

Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain

Kevin Pacheco-Barrios^*1,2, Daniela Martinez-Magallanes^*1, Cristina Xicota Naqui^1,3, Marianna Daibes¹, Elly Pichardo¹, Alejandra Cardenas-Rojas¹, David Crandell⁴, Anahita Dua⁵, Abhishek Datta^6,7, Wolnei Caumo^8,9,10, Felipe Fregni¹

¹Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, ²Vicerrectorado de Investigación, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, ³Nursing Department, Universitat Internacional de Catalunya, ⁴Spaulding Rehabilitation Hospital, Harvard Medical School, ⁵Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, ⁶Research and Development, Soterix Medical, ⁷City College of New York, ⁸Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), ⁹Laboratory of Pain & Neuromodulation, Hospital de Clinicas de Porto Alegre (HCPA), ¹⁰Pain and Palliative Care Service, Hospital de Clinicas de Porto Alegre (HCPA)

The goal of this study is to describe a protocol for the home-based delivery of remotely supervised transcranial direct current stimulation (RS-tDCS) conserving the standard procedures of in-clinic practice, including safety, reproducibility, and tolerability. The participants included will be patients with phantom limb pain (PLP).