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Shenyang Agricultural University

3 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Chen Yang¹, Jiaxue Zhang¹, Fei Mo², Peipei Zhang¹, Qingqing Li¹, Jiye Zhang¹

¹School of Pharmacy, Health Science Center, Xi’an Jiaotong University, ²Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University

Periprosthetic joint infection (PJI) caused by dangerous pathogens is common in clinical orthopedics. Existing animal models cannot accurately simulate the actual situation of PJI. Here, we established a Candida albicans biofilm-associated PJI mouse model to research and develop new therapeutics for PJI.

Immunology and Infection

Chen Yang¹, Fei Mo², Jiaxue Zhang¹, Peipei Zhang¹, Qingqing Li¹, Jiye Zhang¹

We establish a mouse model of C.albicans-associated catheter-related infection (CRI), in which biofilm forms on the catheter, and the interaction between C.albicans and host correlates well with the clinical CRI. This model helps screen therapies for C.albicans biofilm-associated CRI, laying a foundation for clinical transformation.

Biology

RNA Interference in the Egg Parasitoid, Trichogramma dendrolimi Matsumura

Long-xi Zhang¹, Qian-jin Dong¹, Shuai Yang¹, Wu-nan Che¹, Li-sheng Zhang², Jin-cheng Zhou^1,2, Hui Dong¹

¹College of Plant Protection, Shenyang Agricultural University, ²State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences

The manipulation of RNA interference (RNAi) presents a formidable challenge in many parasitoid species with diminutive size, such as Trichogramma wasps. This study delineated an efficient RNAi method in Trichogramma denrolimi. The present methodology provides a robust model for investigating gene regulation in Trichogramma wasps.