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RTI International

2 ARTICLES PUBLISHED IN JoVE

Medicine

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Phillip G. Durham¹, Shumaila N. Hanif², Lucia Garcia Contreras², Ellen F. Young³, Miriam S. Braunstein³, Anthony J. Hickey¹

¹RTI International, ²Oklahoma University Health Science Center, ³University of North Carolina at Chapel Hill

During development of drugs for pulmonary delivery, it is necessary to evaluate pharmacokinetics and efficacy in an animal model. We present a method to build a disposable aerosol dispersion system from of-the-shelf components that can be used to administer intrapulmonary dry powder aerosol to rodents.

JoVE Core

Disposable Dosators Intended for Dry Powder Delivery to Mice

Sara E. Maloney¹, Ian E. Stewart¹, Jeffrey B. Mecham¹, Mercedes Gonzalez-Juarrero², Bernd Meibohm³, Anthony J. Hickey¹

¹Technology Advancement and Commercialization, RTI International, ²Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, ³Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center

Pharmaceutical dry powder development necessitates reliable in vivo testing, often using a murine model. Device technology for accurately and reproducibly delivering dry powder aerosols to mice is restricted. This study presents disposable dosators for pulmonary drug delivery at mouse-relevant doses, aiding initial proof-of-concept research.