Synthesis and Characterization of Charged Hydrogels for the Extended Delivery of VancomycinCarl T. Gustafson 1, Felix Boakye-Agyeman 2, Cassandra L. Brinkman 3, Joel M. Reid 1, Robin Patel 3, Zeljko Bajzer 4,5, Mahrokh Dadsetan 5, Michael J. Yaszemski 5,6,1
1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Graduate School, Mayo Clinic College of Medicine, Mayo Clinic, 2Pharmacometrics Center, Duke Clinical Research Institute, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, 4Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, 5Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Mayo Clinic, 6Department of Orthopedic Surgery, Mayo Graduate School, Mayo Clinic College of Medicine, Mayo Clinic
Here we describe the synthesis and use of oligo(poly(ethylene glycol)fumarate) / sodium methacrylate (OPF/SMA) charged copolymers as an affinity based delivery system for vancomycin.
