Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy StudyMonica Ferro *1, Franca Castiglione *1, Carlo Punta 1, Lucio Melone 1,2, Walter Panzeri 3, Barbara Rossi 4, Francesco Trotta 5, Andrea Mele 1
1Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 2Università degli studi e-Campus, 3ICRM, CNR - Consiglio Nazionale delle Ricerche, 4Elettra Sincrotrone Trieste, 5Department of Chemistry, University of Torino
The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in detail.
