The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the MouseJohn P. Dougherty 1, Danielle A. Springer 2, Marvin C. Gershengorn 1
1Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 2Murine Phenotyping Core, National Heart, Lung, and Blood Institute, National Institutes of Health
Fatigue is a common, undertreated and frequently poorly-understood symptom in many diseases and disorders. New preclinical assays of fatigue may help to improve current understanding and future treatment of fatigue. To that end, the current protocol provides a novel means of measuring fatigue-like behavior in the mouse.
