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University of Barcelona (UB)

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Ignasi Casanellas^1,2, Anna Lagunas^3,1, Iro Tsintzou¹, Yolanda Vida^4,5, Daniel Collado^4,5, Ezequiel Pérez-Inestrosa^4,5, Cristina Rodríguez-Pereira⁶, Joana Magalhaes^3,6, Pau Gorostiza^1,3,7, José A. Andrades^8,3, José Becerra^8,3,5, Josep Samitier^1,3,2

¹Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), ²Department of Engineering Electronics, University of Barcelona (UB), ³Networking Biomedical Research Center (CIBER), ⁴Instituto de Investigacin Biomédica de Málaga (IBIMA), Department of Organic Chemistry, Universidad de Málaga (UMA), ⁵Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, ⁶Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC), Grupo de Reumatolog ía, Instituto de Investigación Biomèdica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), ⁷Institució Catalana de Recerca i Estudis Avançats (ICREA), ⁸Instituto de Investigación Biomédica de Málaga (IBIMA), Department of Cell Biology, Genetics and Physiology, Universidad de Málaga (UMA)

A method to obtain dendrimer-based uneven nanopatterns that permit the nanoscale control of local arginine-glycine-aspartic acid (RGD) surface density is described and applied for the study of cell adhesion and chondrogenic differentiation.

Medicine

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Daina Martínez-Falguera^*1,2, Edgar Fadeuilhe^*3, Albert Teis³, Julia Aranyo³, Raquel Adeliño^1,3, Felipe Bisbal^3,4, Oriol Rodriguez-Leor^3,4, Carolina Gálvez-Montón^1,3,4

¹ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), ²Faculty of Medicine, University of Barcelona (UB), ³Heart Institute (iCOR), Germans Trias i Pujol University Hospital, ⁴CIBER Cardiovascular, Instituto de Salud Carlos III

Myocardial infarction (MI) animal models that emulate the natural process of the disease in humans are crucial to understanding pathophysiological mechanisms and testing the safety and efficacy of new emergent therapies. Here, we describe an MI swine model created by deploying a percutaneous embolization coil.