Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in BloodMarie-Claire Devilder 1,2,3, Mélinda Moyon 1,2,3, Xavier Saulquin 1,2, Laetitia Gautreau-Rolland 1,2
1CRCINA, Inserm, CNRS, Université d'Angers, Université de Nantes, 2LabEx IGO, "Immunotherapy, Graft, Oncology", 3CHU Nantes, France
We describe a method for the production of human antibodies specific for an antigen of interest, starting from rare B cells circulating in human blood. Generation of these natural antibodies is efficient and rapid, and the antibodies obtained can discriminate between highly related antigens.
