Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion DynamicsTaylor C. Brown 1, Norman G. Nicolson 2, Joyce Cheng 1, Reju Korah 1, Tobias Carling 1
1Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, 2Yale New Haven Hospital
This study demonstrates the utility and ease of quantitative cell membrane extension measurement and its correlation to adhesive capacity of cells. As a representative example, we show here that Dickkopf-related protein 3 (DKK3) promotes increased lobopodia formation and cell adhesiveness in adrenocortical carcinoma cells in vitro.
