Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme XenograftsUlrich Jarry *1,2, Noémie Joalland *1,2, Cynthia Chauvin *1,2, Béatrice Clemenceau 1,2,3, Claire Pecqueur 1,2, Emmanuel Scotet 1,2
1INSERM, CNRS, Université d'Angers, Université de Nantes, CRCINA, 2Immunotherapy, Graft, Oncology, LabEx IGO, 3Hopital de Nantes, Hotel Dieu
Here, we present a protocol for the preparation and the stereotaxic administration of allogeneic human lymphocytes in immunodeficient mice carrying orthotopic human primary brain tumors. This study provides a proof-of-concept for both the feasibility and the antitumor efficacy of intrabrain-delivered cellular immunotherapies.
