In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor FunctionDongrui Wang 1,2, Renate Starr 1, Darya Alizadeh 1, Xin Yang 1, Stephen J. Forman *1, Christine E. Brown *1
1Department of Hematology & Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratory, City of Hope Beckman Research Institute and Medical Center, 2Irell and Manella Graduate School of Biological Sciences, City of Hope Beckman Research Institute and Medical Center
Here, we describe an in vitro co-culture method to recursively challenge tumor-targeted T cells, which allows for phenotypic and functional analysis of antitumor T cell activity.
