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Biomedical Sciences Research Centre "Al. Fleming"

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Myrto Denaxa^1,2, Guilherme Neves³, Juan Burrone³, Vassilis Pachnis¹

¹Nervous System Development and Homeostasis Laboratory, The Francis Crick Institute, ²Neuroscience Centre, Biomedical Sciences Research Centre "Al. Fleming", ³Centre for Developmental Neurobiology, King's College London

Here we present a protocol, designed to use chemogenetic tools to manipulate the activity of cortical interneuron progenitors transplanted into the cortex of early postnatal mice.