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Brown University, Rhode Island Hospital

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

Real-Time Monitoring of Human Glioma Cell Migration on Dorsal Root Ganglion Axon-Oligodendrocyte Co-Cultures

John P. Zepecki¹, Kristin M. Snyder², Nikos Tapinos^1,3

¹Molecular Neuro-oncology Laboratory, Brown University, Rhode Island Hospital, ²University of Minnesota, College of Veterinary Medicine, ³Department of Neurosurgery, Brown University

Here we present an ex-vivo mixed monolayer culture system for the study of human glioma cell (hGC) migration in real-time. This model provides the ability to observe interactions between hGCs and both myelinated and non-myelinated axons within a compartmentalized chamber.