Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in PatientsGiuditta Viticchié 1, Ian Powley 1, Constantinos Demetriou 1, James Cooper 1, Michael Butterworth 1, Meeta Patel 1, Naila Abid 1, Gareth Miles 1, Lynne Howells 1, Howard Pringle 1, Marion MacFarlane 2, Catrin Pritchard 1
1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit
This paper describes methods for the generation, drug treatment, and analysis of patient-derived explants for assessing tumor drug responses in a live, patient-relevant, preclinical model system.
