Laboratory-Scale Emulsification Process of a Recombinant Adenovirus Vaccine with a Water-In-Oil-In-Water AdjuvantManon Broutin 1,2, Matthieu Bricaud 2, Fleur Costa 1, Jennifer Maye 2, Jérémie Bornères 2, Juliette Ben Arous 2, Nicolas Versillé 2, Bernard Klonjkowski 1
1UMR Virologie, INRAE, ANSES, Ecole Nationale Vétérinaire d'Alfort, 2SEPPIC - Air Liquide Healthcare Specialty Ingredients, Paris La Défense
This manuscript describes a simple method for the formulation and control of vaccines with a water-in-oil-in-water adjuvant at the laboratory scale, compatible with the safety requirements of live recombinant vaccines.
