우리는 건강 연구 (CIHR)이 연구 자금을 제공 온타리오 Neurotrauma 재단 (ONF)의 캐나다 연구소 감사하고 싶습니다.

<ol>
	<li>Browne, G. J., Lam, L. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Concussive+head+injury+in+children+and+adolescents+related+to+sports+and+other+leisure+physical+activities.">Concussive head injury in children and adolescents related to sports and other leisure physical activities.</a> Br. J .Sports Med. 40, 163-168 (2006).</li><li>McCrory, P., Collie, A., Anderson, V., Davis, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Can+we+manage+sport+related+concussion+in+children+the+same+as+in+adults.">Can we manage sport related concussion in children the same as in adults.</a> Br. J .Sports Med. 38, 516-519 (2004).</li><li>Brolinson, P. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Analysis+of+linear+head+accelerations+from+collegiate+football+impacts.">Analysis of linear head accelerations from collegiate football impacts.</a> Curr. Sports Med. Rep. 5, 23-28 (2006).</li><li>Duma, S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Analysis+of+real-time+head+accelerations+in+collegiate+football+players.">Analysis of real-time head accelerations in collegiate football players.</a> Clin. J. Sport Med. 15, 3-8 (2005).</li><li>Schnebel, B., Gwin, J. T., Anderson, S., Gatlin, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=In+vivo+study+of+head+impacts+in+football:+a+comparison+of+National+Collegiate+Athletic+Association+Division+I+versus+high+school+impacts.">In vivo study of head impacts in football: a comparison of National Collegiate Athletic Association Division I versus high school impacts.</a> Neurosurgery. 60, 490-495 (2007).</li><li>Chen, J. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Functional+abnormalities+in+symptomatic+concussed+athletes:+an+fMRI+study.">Functional abnormalities in symptomatic concussed athletes: an fMRI study.</a> Neuroimage. 22, 68-82 (2004).</li><li>Glover, G. H., Law, C. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Spiral-in/out+BOLD+fMRI+for+increased+SNR+and+reduced+susceptibility+artifacts.">Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts.</a> Magn. Reson. Med. 46, 515-522 (2001).</li><li>Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., Behrens, T. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Tract-based+spatial+statistics:+voxelwise+analysis+of+multi-subject+diffusion+data.">Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data.</a> Neuroimage. 31, 1487-1505 (2006).</li><li>Gibson, E., Gao, F., Black, S. E., Lobaugh, N. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Automatic+Segmentation+of+White+Matter+Hyperintensities+in+FLAIR+images+at+3T.">Automatic Segmentation of White Matter Hyperintensities in FLAIR images at 3T.</a> J. Magn. Reson. Imaging. , (2009).</li><li>McIntosh, A. R., Bookstein, F. L., Haxby, J. V., Grady, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Spatial+pattern+analysis+of+functional+brain+images+using+Partial+Least+Squares.">Spatial pattern analysis of functional brain images using Partial Least Squares.</a> NeuroImage. 3, 143-157 (1996).</li><li>McIntosh, A., Gonzalez-Lima, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Network+interactions+among+limbic+cortices,+basal+forebrain+and+cerebellum+differentiate+a+tone+conditioned+as+a+Pavlovian+excitor+or+inhibitor:+fluorodeoxyglucose+and+covariance+structural+modeling.">Network interactions among limbic cortices, basal forebrain and cerebellum differentiate a tone conditioned as a Pavlovian excitor or inhibitor: fluorodeoxyglucose and covariance structural modeling.</a> J. Neurophysiol. 72, 1717-1733 (1994).</li><li>McIntosh, A., Lobaugh, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Partial+least+squares+analysis+of+neuroimaging+data:+applications+and+advances.">Partial least squares analysis of neuroimaging data: applications and advances.</a> Neuroimage. 23, 250-263 (2004).</li><li>Frackowiack, R. S. J., Frith, C. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Human Brain Function. , (2003).</li></ol>

관심 없음 충돌 선언하지 않습니다.

우리는 뇌의 백질에 가장 큰 영향을 보여주 그 젊은이는 뇌 활동의 가장 큰 개편하고, 가장 긴 행동 및 신경 복구 기간을 표시 것으로 예측. 그것은 우리 어린이와 청소년에게 구체적인 연구 증거를 기반으로 복구 프로토콜을 설정할 수있게되므로 본 연구는 소아 후 뇌진탕 이벤트의 더 나은 이해를 제공하고 의료에 큰 영향을 미칠 것입니다. 이러한 프로토콜은 다음 부모, 코치와 의사를 포함하?...

<table border="1"><tbody><tr><td> 이름 </td><td> 회사 </td><td> 댓글 </td></tr><tr><td> AccuGait 휴대용의 게이트와 균형 플랫폼 (밸런스 평가) </td><td> AMTI </td><td> <a href="http://www.amti.biz/">www.amti.biz</a> </td></tr><tr><td> NetForce 잔액 데이터 수집 소프트웨어 </td><td> AMTI </td><td> <a href="http://www.amti.biz/">www.amti.biz</a> </td></tr><tr><td> 시각적 충돌 돔 </td><td></td><td> 연구자에 의해 가공, 이후 모델 : 로벨 MR, 콜린스 MW. 대학 축구 선수의 평가 Neuropsychological. J 헤드 외상 Rehabil. 1998, 13 (2) :9 - 26. </td></tr><tr><td> Airex 밸런스 패드 </td><td> Airex </td><td> <a href="http://www.bebalanced.net/">www.bebalanced.net</a> </td></tr><tr><td> Smedlay의 동력계, 100kg (그립 강도) </td><td> TTM, 도쿄 </td><td></td></tr><tr><td> 홈 붙이 Pegboard 테스트 </td><td> 라파예트 악기 회사 </td><td> <a href="http://www.lafayetteinstrument.com/">www.lafayetteinstrument.com</a> </td></tr><tr><td> 액슨 점프 매트 </td><td> Vacumed </td><td> <a href="http://www.vacumed.com/">www.vacumed.com</a> </td></tr><tr><td> 강도 바 </td><td></td><td> 연구자에 의해 조작된 : <ul><li> 31 &quot;티타늄 라크로스 처리 </li><li> 두 개의 40 &quot;유틸리티 체인 </li><li> 24 &quot;X 26&quot;합판 플랫폼 </li><li> 두 부두 링 체결 </li><li> 투 U - 볼트 (1 &quot;폭) </li></ul></td></tr><tr><td> 헤드 충격 텔레 메 (HIT) 시스템 </td><td> Simbex </td><td> <a href="http://www.simbex.com/">www.simbex.com</a> </td></tr><tr><td> 포스트 뇌진탕 증상의 규모는 (PCS - R) 개정 </td><td></td><td> 에서 적응 : 로벨 MR, 콜린스 MW. 대학 축구 선수의 평가 Neuropsychological. J 헤드 외상 Rehabil. 1998, 13 (2) :9 - 26. </td></tr><tr><td> GE 디스커버리 ™ MR750 3.0T MRI 스캐너 </td><td> GE </td><td> <a href="http://www.gehealthcare.com/">www.gehealthcare.com</a> </td></tr><tr><td> GE 8 채널 헤드 코일 </td><td> GE </td><td> <a href="http://www.gehealthcare.com/">www.gehealthcare.com</a> </td></tr><tr><td> Lumitouch 회신 시스템 </td><td> Lightwave 의료 산업 </td><td> 밴쿠버, BC 1- (604) -875-4529 </td></tr><tr><td> 위로 투영 화면 (fMRI 자극을 보여주고 용) </td><td> 알 수없는 </td><td></td></tr><tr><td> 일회용 발포 귀는 플러그 </td><td> PAR 주식 회사 </td><td> <a href="http://www.parinc.com/">www.parinc.com</a> </td></tr><tr><td> Neuropsychological 테스트 </td><td> 피어슨 평가 </td><td> <a href="http://www.pearsonassessments.com/">www.pearsonassessments.com</a> </td></tr></tbody></table>

an investigation of the effects of sports-related concussion in youth using functional magnetic resonance imaging and the head impact telemetry system

스포츠에 참여하는 아동에서 가장 흔히보고 부상 중 하나는 뇌진탕이나 가벼운 외상성 뇌 손상 (mTBI) 1입니다. 이러한 경쟁 하키 같은 단체 경기에 참여 아동 및 청소년은 다른 여가 활동이 실제에 참여 어린이에 비해 심한 뇌진탕 고통을 거의 6 배 이상 높습니다. mTBI의 가장 일반적인인지 sequelae은 어린이와 성인과 유사하게 나타납니다 동안, 어린이 결과의 복구 프로필과 광범로 사전에 부상 특성 (예 : 성별) 및 부상 세부 사항 (의 영향이가, 2 크게 알려지지 않은 유적 예 : 크기와 방향 장기 결과에 미치는 영향)의. 같은 하키와 같은 경쟁력있는 스포츠, 뇌진탕은 청소년 특성과 기능에서 발생하고 이것을 결과 다음과 같은 부상을 연관하기 전에 미리 부상 데이터를 얻기 위해 미리 게시 디자인을 활용할 수있는 드문 기회를 허용합니다. 우리의 주요 목표는 아동 및 청소년에게 구체적인 연구 증거를 기반으로 소아 뇌진탕 진단 및 관리를 수정하는 것입니다. 이 작업을 수행하려면 우리는 새로운 멀티 모달 및 통합 접근 방식을 사용 청소년의 두부 외상의 즉각적인 효과를 1.Evaluate 2.Monitor 이후 뇌진탕 증상의 해상도 (PCS) 및 복구하는 동안인지 성능 뇌 손상 및 복구를 확인할 수있는 새로운 방법을 3.Utilize 우리의 목표를 달성하기 위해, 우리는 머리의 충격 텔레 메 (HIT) 시스템을 구축했습니다. (Simbex, 레바논, NH, 미국). 5 - 연락처 스포츠 참여 3 중에 실시간으로 머리 가속을 측정하기위한 하나의 축 accelerometers로,이 시스템은 상용 이스턴 S9 하키 헬멧 (반 누이, CA, 미국 이스턴 - 벨 스포츠) equips. telemetric 기술을 사용하여 가속 및 스포츠 참여하는 동안 모든 헤드 영향의 위치의 크기는 객관적으로 감지하고 기록하실 수 있습니다. 이들은 진탕 머리 부상 6 가장 민감한 대뇌 지역이기 때문에 우리는인지 작업의 성능 동안에도 집중하는 기능성 자기 공명 영상 (fMRI)를 사용하고 중간 측두엽과 전두엽 돌출부에 특별히 신경 활동의 변화를 평가. 마지막으로, 우리는 뇌의 백질에 손상에 민감한 구조 영상​​ 자료를 수집하고 있습니다.

Watch this Scientific Journal Video about An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System at JoVE

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

이 문서는 온화한 외상성 뇌 손상 진단 및 청소년의 회복에 멀티 모달 접근법의 개요를 제공합니다. 이 접근법은 기능적인 자기 공명 영상과인지 테스트하는 동안 머리 영향과 뇌의 활동 사이의 관계를 모니터하기 위해 헤드 충​​격 텔레 메 트리 시스템과 neuropsychological 테스트를 결합한 제품입니다.

기능성 자기 공명 이미징 및 머리 충격 텔레 메 트리 시스템을 사용하는 청소년의 스포츠 관련 뇌진탕의 효과 조사

One of the most commonly reported injuries in children who participate in sports is concussion or mild traumatic brain injury (mTBI)1. Children and youth ...

an-investigation-effects-sports-related-concussion-youth-using

Research

JoVE Journal

Medicine

15.7K 조회수.  University of Toronto. 이 문서는 온화한 외상성 뇌 손상 진단 및 청소년의 회복에 멀티 모달 접근법의 개요를 제공합니다. 이 접근법은 기능적인 자기 공명 영상과인지 테스트하는 동안 머리 영향과 뇌의 활동 사이의 관계를 모니터하기 위해 헤드 충​​격 텔레 메 트리 시스템과 neuropsychological 테스트를 결합한 제품입니다.

비디오: An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF. Current technologies for CMR are time consuming and difficult to implement in clinical practice. Feature tracking is a technology that can lead to more automization and robustness of quantitative analysis of medical images with less time consumption than comparable methods.
Methods: An automatic or manual input in a single phase serves as an initialization from which the system starts to track the displacement of individual patterns representing anatomical structures over time. The specialty of this method is that the images do not need to be manipulated in any way beforehand like e.g. tagging of CMR images.
Results: The method is very well suited for tracking muscular tissue and with this allowing quantitative elaboration of myocardium and also blood flow.
Conclusions: This new method offers a robust and time saving procedure to quantify myocardial tissue and blood with displacement, velocity and deformation parameters on regular sequences of CMR imaging. It therefore can be implemented in clinical practice.

An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF.

기능 추적을 사용하여 자기 공명이 유래 심근 스트레인 평가

Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that ...

연구

의학

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion tensor imaging (DTI) techniques provide information on the microstructural processes of the cerebral white matter (WM) in vivo. The present applications are designed to investigate differences of WM involvement patterns in different brain diseases, especially neurodegenerative disorders, by use of different DTI analyses in comparison with matched controls. 	
DTI data analysis is performed in a variate fashion, i.e. voxelwise comparison of regional diffusion direction-based metrics such as fractional anisotropy (FA), together with fiber tracking (FT) accompanied by tractwise fractional anisotropy statistics (TFAS) at the group level in order to identify differences in FA along WM structures, aiming at the definition of regional patterns of WM alterations at the group level. Transformation into a stereotaxic standard space is a prerequisite for group studies and requires thorough data processing to preserve directional inter-dependencies. The present applications show optimized technical approaches for this preservation of quantitative and directional information during spatial normalization in data analyses at the group level. On this basis, FT techniques can be applied to group averaged data in order to quantify metrics information as defined by FT. Additionally, application of DTI methods, i.e. differences in FA-maps after stereotaxic alignment, in a longitudinal analysis at an individual subject basis reveal information about the progression of neurological disorders. Further quality improvement of DTI based results can be obtained during preprocessing by application of a controlled elimination of gradient directions with high noise levels.	
In summary, DTI is used to define a distinct WM pathoanatomy of different brain diseases by the combination of whole brain-based and tract-based DTI analysis.

Diffusion tensor imaging (DTI) basically serves as an MRI-based tool to identify in vivo the microstructure of the brain and pathological processes due to neurological disorders within the cerebral white matter. DTI-based analyses allow for application to brain diseases both at the group level and in single subject data.

neurodegenerative 질병의 분석에서 확산 텐서 자기 공명 영상

Diffusion tensor imaging (DTI) techniques provide information on the microstructural processes of the cerebral white matter (WM) in vivo. The present ...

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling molecules that affect multiple organs; they modulate gut motility and hormone production, and alter vascular tone, glucose metabolism, lipid metabolism, and energy utilization. Changes in fecal bile acids may alter the gut microbiome and promote colon pathology including cholerrheic diarrhea and colon cancer. Key regulators of fecal bile acid composition are the small intestinal Apical Sodium-dependent Bile Acid Transporter (ASBT) and fibroblast growth factor-19 (FGF19). Reduced expression and function of ASBT decreases intestinal bile acid up-take. Moreover, in vitro data suggest that some FDA-approved drugs inhibit ASBT function. Deficient FGF19 release increases hepatic bile acid synthesis and release into the intestines to levels that overwhelm ASBT. Either ASBT dysfunction or FGF19 deficiency increases fecal bile acids and may cause chronic diarrhea and promote colon neoplasia. Regrettably, tools to measure bile acid malabsorption and the actions of drugs on bile acid transport in vivo are limited. To understand the complex actions of bile acids, techniques are required that permit simultaneous monitoring of bile acids in the gut and metabolic tissues. This led us to conceive an innovative method to measure bile acid transport in live animals using a combination of proton (1H) and fluorine (19F) magnetic resonance imaging (MRI). Novel tracers for fluorine (19F)-based live animal MRI were created and tested, both in vitro and in vivo. Strengths of this approach include the lack of exposure to ionizing radiation and translational potential for clinical research and practice.

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Tools to diagnose bile acid malabsorption and measure bile acid transport in vivo are limited. An innovative approach in live animals is described that utilizes combined proton (1H) plus fluorine (19F) magnetic resonance imaging; this novel methodology has translational potential to screen for bile acid malabsorption in clinical practice.

멀티 플루오르 담즙 산 및 사용<em&gt; 생체</em&gt; 자기 공명 영상은 측정하는 담즙 산 전송

Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling ...

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, which is critically important in health and disease, can be measured in vivo and noninvasively in humans via phosphorus-31 magnetic resonance spectroscopy (31PMRS). However, the approach has not been widely adopted in translational and clinical research, with variations in methodology and limited guidance from the literature. Increased optimization, standardization, and dissemination of methods for in vivo 31PMRS would facilitate the development of targeted therapies to improve OXPHOS capacity and could ultimately favorably impact cardiovascular health. 31PMRS produces a noninvasive, in vivo measure of OXPHOS capacity in human skeletal muscle, as opposed to alternative measures obtained from explanted and potentially altered mitochondria via muscle biopsy. It relies upon only modest additional instrumentation beyond what is already in place on magnetic resonance scanners available for clinical and translational research at most institutions. In this work, we outline a method to measure in vivo skeletal muscle OXPHOS. The technique is demonstrated using a 1.5 Tesla whole-body MR scanner equipped with the suitable hardware and software for 31PMRS, and we explain a simple and robust protocol for in-magnet resistive exercise to rapidly fatigue the quadriceps muscle. Reproducibility and feasibility are demonstrated in volunteers as well as subjects over a wide range of functional capacities.

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

This work demonstrates the feasibility of an in vivo phosphorus-31 magnetic resonance spectroscopy (31PMRS) technique to quantify mitochondrial oxidative phosphorylation (OXPHOS) capacity in human skeletal muscle.

인-31 자기 공명 분광학 : 측정을위한 도구<em&gt; 생체</em인간의 골격 근육에&gt; 미토콘드리아 산화 적 인산화 능력

Skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, which is critically important in health and disease, can be measured in vivo ...

Cardiac Magnetic Resonance Imaging at 7 Tesla

CMR at an ultra-high field (magnetic field strength B0&#160;&#8805; 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher magnetic field strengths and potentially provides improved signal contrast and spatial resolution. While promising results have been achieved, ultra-high field CMR is challenging due to energy deposition constraints and physical phenomena such as transmission field non-uniformities and magnetic field inhomogeneities. In addition, the magneto-hydrodynamic effect renders the synchronization of the data acquisition with the cardiac motion difficult. The challenges are currently addressed by explorations into novel magnetic resonance technology. If all impediments can be overcome, ultra-high field CMR may generate new opportunities for functional CMR, myocardial tissue characterization, microstructure imaging or metabolic imaging. Recognizing this potential, we show that multi-channel radio frequency (RF) coil technology tailored for CMR at 7 Tesla together with higher order B0 shimming and a backup signal for cardiac triggering facilitates high fidelity functional CMR. With the proposed setup, cardiac chamber quantification can be accomplished in examination times similar to those achieved at lower field strengths. To share this experience and to support the dissemination of this expertise, this work describes our setup and protocol tailored for functional CMR at 7 Tesla.

The sensitivity gain inherent to ultrahigh field magnetic resonance holds promise for high spatial resolution imaging of the heart. Here, we describe a protocol customized for functional cardiovascular magnetic resonance (CMR) at 7 Tesla using an advanced multi-channel radio-frequency coil, magnetic field shimming and a triggering concept.

CMR at an ultra-high field (magnetic field strength B0&#160;&#8805; 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher ...

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Meni&#232;re's Disease Ears and Normal Hearing Ears

Analysis of neural structures in Meni&#232;re's Disease (MD) is of importance, since a loss of such structures has previously been proposed for this patient group but has yet to be confirmed. This protocol describes a method of in vivo evaluation of neural changes especially well suitable for cranial nerve analysis using magnetic resonance imaging (MRI). MD-patients and normal hearing persons were examined in a 3-T MR-scanner using a scan protocol including strongly T2-weighted 3D gradient-echo-sequence (3D-CISS). In the patient group, MD was additionally confirmed using MRI-based assessment of endolymphatic hydrops. Morphometric analysis was performed using a freeware DICOM viewer. Evaluation of cranial nerves included measurements of cross-sectional areas (CSAs) of the nerves at different levels as well as orthogonal diametric measurements.

&lt;em&gt;In Vivo&lt;/em&gt; Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Meni&amp;#232;re&#039;s Disease Ears and Normal Hearing Ears

To evaluate morphological changes of cranial nerves such as loss of neural structures or swelling of cranial nerves in Meni&#232;re&#39;s Disease (MD) or in healthy persons in vivo, a protocol of evaluation has been developed using magnetic resonance imaging (MRI). Additional MRI-based confirmation of MD was performed.

Vivo에서 Menière의 질병 귀 그리고 정상 청력 귀에 자기 공명 화상 진 찰을 사용 하 여 인간의 두개골 신경의 형태학 분석

Analysis of neural structures in Meni&#232;re's Disease (MD) is of importance, since a loss of such structures has previously been proposed for this ...

Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

Phase contrast magnetic resonance imaging (PC-MRI) is a noninvasive approach that can quantify flow-related parameters such as blood flow. Previous studies have shown that abnormal blood flow may be associated with systemic vascular risk. Thus, PC-MRI can facilitate the translation of data obtained from animal models of cardiovascular diseases to pertinent clinical investigations. In this report, we describe the procedure for measuring blood flow in the common carotid artery (CCA) of rats using cine-gated PC-MRI and discuss relevant analysis methods. This procedure can be performed in a live, anesthetized animal and does not require euthanasia after the procedure. The proposed scanning parameters yield repeatable measurements for blood flow, indicating excellent reproducibility of the results. The PC-MRI procedure described in this article can be used for pharmacological testing, pathophysiological assessment, and cerebral hemodynamics evaluation.

The overall goal of this procedure is to measure the blood flow in the rat common carotid artery by using noninvasive phase contrast magnetic resonance imaging.

쥐 일반적인 경 동맥에 단계 대조 자기 공명 영상

Phase contrast magnetic resonance imaging (PC-MRI) is a noninvasive approach that can quantify flow-related parameters such as blood flow. Previous ...

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Participation in organized sports makes a significant contribution to youth development, but places youth at a higher risk for sustaining a concussion. To date, return-to-activity decision-making has been anchored in the monitoring of self-reported concussion symptoms and neurocognitive testing. However, multi-modal assessments that corroborate objective physiological measures with traditional subjective symptom reporting are needed and can be valuable. Heart rate variability (HRV) is a non-invasive physiological indicator of the autonomic nervous system, capturing the reciprocal interplay between the sympathetic and parasympathetic nervous systems. There is a dearth of literature exploring the effect of concussion on HRV in youth athletes, and developmental differences preclude the application of adult findings to a pediatric population. Further, the current state of HRV methodology has primarily included short-term (5-15 min) recordings, by using resting state or short-term physical exertion testing to elucidate changes following concussion. The novelty in utilizing a 24 h&#160;recording methodology is that it has the potential to capture natural variation in autonomic function, directly related to the activities a youth athlete performs on a regular basis. Within a prospective, longitudinal research setting, this novel approach to quantifying autonomic function can provide important information regarding the recovery trajectory, alongside traditional self-report symptom measures. Our objectives regarding a 24 h recording methodology were to (1) evaluate the physiological effects of a concussion in youth athletes, and (2) describe the trajectory of physiological change, while considering the resolution of self-reported post-concussion symptoms. To achieve these objectives, non-invasive sensor technology was implemented. The raw beat-to-beat time intervals captured can be transformed to derive time domain and frequency domain measures, which reflect an individual&#39;s ability to adapt and be flexible to their ever-changing environment. By using non-invasive heart rate technology, autonomic function can be quantified outside of a traditional controlled research setting.

We demonstrate a 24 h heart rate recording methodology to evaluate the influence of concussion across the recovery trajectory in youth athletes, within an ecologically valid context.

자율 기능 청소년 선수에 뇌 진 탕을 다음: 24 시간 녹화 방법론을 사용 하 여 심장 박동의 변화 탐구

Participation in organized sports makes a significant contribution to youth development, but places youth at a higher risk for sustaining a concussion. To ...

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Specific ventilation imaging (SVI) is a functional magnetic resonance imaging technique capable of quantifying specific ventilation &#8213; the ratio of the fresh gas entering a lung region divided by the region&#8217;s end-expiratory volume &#8213; in the human lung, using only inhaled oxygen as a contrast agent. Regional quantification of specific ventilation has the potential to help identify areas of pathologic lung function. Oxygen in solution in tissue shortens the tissue&#8217;s longitudinal relaxation time (T1), and thus a change in tissue oxygenation can be detected as a change in T1-weighted signal with an inversion recovery acquired image. Following an abrupt change between two concentrations of inspired oxygen, the rate at which lung tissue within a voxel equilibrates to a new steady-state reflects the rate at which resident gas is being replaced by inhaled gas. This rate is determined by specific ventilation. To elicit this sudden change in oxygenation, subjects alternately breathe 20-breath blocks of air (21% oxygen) and 100% oxygen while in the MRI scanner. A stepwise change in inspired oxygen fraction is achieved through use of a custom three-dimensional (3D)-printed flow bypass system with a manual switch during a short end-expiratory breath hold. To detect the corresponding change in T1, a global inversion pulse followed by a single shot fast spin echo sequence was used to acquire two-dimensional T1-weighted images in a 1.5&#160;T MRI scanner, using an eight-element torso coil. Both single slice and multi-slice imaging are possible, with slightly different imaging parameters. Quantification of specific ventilation is achieved by correlating the time-course of signal intensity for each lung voxel with a library of simulated responses to the air/oxygen stimulus. SVI estimations of specific ventilation heterogeneity have been validated against multiple breath washout and proved to accurately determine the heterogeneity of the specific ventilation distribution.

Specific ventilation imaging is a functional magnetic resonance imaging technique that allows for quantification of regional specific ventilation in the human lung, using inhaled oxygen as a contrast agent. Here, we present a protocol to collect and analyze specific ventilation imaging data.

양성자 자기 공명 영상 및 조 영제로 산소를 사용 하 여 인간의 폐에 특정 통풍의 정량 매핑

Specific ventilation imaging (SVI) is a functional magnetic resonance imaging technique capable of quantifying specific ventilation &#8213; the ratio of ...

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Magnetic resonance imaging (MRI) is an important tool for the clinical assessment of cardiovascular morphology and heart function. It is also the recognized standard-of-care for blood flow quantification based on phase contrast MRI. While such measurement of blood flow has been possible in adults for decades, methods to extend this capability to fetal blood flow have only recently been developed.
Fetal blood flow quantification in major vessels is important for monitoring fetal pathologies such as congenital heart disease (CHD) and fetal growth restriction (FGR). CHD causes alterations in the cardiac structure and vasculature that change the course of blood in the fetus. In FGR, the path of blood flow is altered through the dilation of shunts such that the oxygenated blood supply to the brain is increased. Blood flow quantification enables assessment of the severity of the fetal pathology, which in turn allows for suitable&#160;in utero&#160;patient management and planning for postnatal care.
The primary challenges of applying phase contrast MRI to the human fetus include small blood vessel size, high fetal heart rate, potential MRI data corruption due to maternal respiration, unpredictable fetal movements, and lack of conventional cardiac gating methods to synchronize data acquisition. Here, we describe recent technical developments from our lab that have enabled the quantification of fetal blood flow using phase contrast MRI, including advances in accelerated imaging, motion compensation, and cardiac gating.

Here we present a protocol for measuring fetal blood flow rapidly with MRI and retrospectively performing motion correction and cardiac gating.