Results: Analysis of Human Platelets to Study Mitochondrial Metabolism
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Conclusion
필기록
The overall goal of this procedure is to determine how either a xenobiotic treatment or a disease state alters cellular metabolism. This method has the potential to reveal how a disease state or an applied toxin affects cellular metabolism. And on
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Here we show isolated human platelets can be used as an accessible ex vivo model to study metabolic adaptations in response to the complex I inhibitor rotenone. This approach employs isotopic tracing and relative quantification by liquid chromatography-mass spectrometry and can be applied to a variety of study designs.