In this protocol, cue reactivity measures an animal's motivation to seek cocaine following absence from cocaine self-administration. Cue reactivity occurs when the rat is re-exposed to the context and cues previously associated with intravenous co
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Cue reactivity is conceptualized as sensitivity to cues linked with drug-taking experiences that contribute to craving and relapse in abstinent humans. Cue reactivity is modeled in rats by measuring attentional orientation toward drug-associated cues that results in appetitive approach behavior in a cue reactivity test following self-administration and forced abstinence.