The orthotopic transplantation of mouse lung adenocarcinoma cells into syngeneic graft recipients allows the study of tumorigenesis in the presence of a fully active immune system under physiological conditions. Of course, the tumors develop into
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Here we describe a minimally invasive syngeneic orthotopic transplantation model of mouse lung adenocarcinoma cells as a time- and cost-reducing model to study non-small cell lung cancer.