Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

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9.1K Views

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10:10 min

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November 2nd, 2018

DOI :

10.3791/55894-v

November 2nd, 2018

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Mark C. Butler¹^,², Jack M. Sullivan¹^,²^,³^,⁴^,⁵^,⁶^,⁷

¹Research Service, VA Western New York Healthcare System, ²Department of Ophthalmology, (Ross Eye Institute), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ³Pharmacology/Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁴Physiology/Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁵Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁶The RNA Institute, University at Buffalo- SUNY, ⁷The SUNY Eye Institute

Podsumowanie

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Keywords Ultrahigh Resolution

Mouse

Optical Coherence Tomography

Intraocular Injection

Retinal Gene Therapy

Subretinal Injection

Vector Delivery

Therapeutic Agent Toxicity

Minimally Invasive

Reproducible

Real time Observation

Retinal Imaging

Proptosis

Scleral Depression

Retinal Pigment Epithelium

Subretinal Space

Injection Outcomes

OCT Imaging

Rozdziały w tym wideo

0:04

Title

0:45

Subretinal Injection

2:37

Injection Site and Subretinal Bleb Mapping

4:03

High Resolution Spectral-Domain Optical Coherence Tomography (HR-SD-OCT) Outer Retinal Degeneration Evaluation

7:47

Results: Representative Outer Retinal Change Quantification and Post-Subretinal Injection 3D Mapping

8:54

Conclusion

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