Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

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5.6K Views

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09:54 min

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February 16th, 2020

DOI :

10.3791/58227-v

February 16th, 2020

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Chun-Nin Lee¹, Li-Hsuan Chiu²^,⁵, Chia-Lang Fang³, Shauh-Der Yeh⁴, Chun S. Zuo⁵, Shih-Ching Chen⁶, Li-Kuo Kuo⁷, Yun-Ming Wang⁸, Wen-Fu Thomas Lai²^,⁵^,⁹

¹Department of Pulmonary and Critical Care Medicine, Taipei Medical University-Shuang Ho Hospital, ²Department of Research and Department of Dentistry, Taipei Medical University / Shuang-Ho Hospital, ³Department of Pathology, Taipei Medical University, ⁴Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, ⁵McLean Imaging Center, McLean Hospital/Harvard Medical School, ⁶Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, ⁷Department of Medicine, Mackay Medical College, ⁸Department of Biological Science and Technology, National Chiao Tung University, ⁹Graduate Institute of Clinical Medicine, Taipei Medical University

Podsumowanie

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Keywords Superparamagnetic Iron Oxide Nanoprobes

Extrapulmonary Tuberculosis Detection

Mycobacterium Tuberculosis

MRI Contrast Agent

Dextran coated Iron Oxide Magnetic Nanoparticles

SPIO conjugated Mycobacterium Tuberculosis Surface Antibodies

Rozdziały w tym wideo

0:04

Title

1:42

Superparamagnetic Iron Oxide (SPIO) Nanoparticle Synthesis

2:54

SPIO-Mycobacterium tuberculosis Surface Antibody (MtbsAb) Synthesis

4:03

Particle Morphology Observation and Relaxation Tier Measurement

4:40

Cell Magnetic Resonance Imaging (MRI)

5:41

BCG Inoculation

6:13

In Vivo MRI

7:30

Results: Representative Extrapulmonary Tuberculosis Detection

9:04

Conclusion

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