Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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9.3K Views

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12:42 min

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January 7th, 2019

DOI :

10.3791/58651-v

January 7th, 2019

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Johannes P.W. Heidbuechel¹^,², Christine E. Engeland¹^,³

¹Department of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), ²Faculty of Biosciences, Heidelberg University, ³Department of Medical Oncology, NCT and Heidelberg University Hospital

Podsumowanie

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Paramyxoviruses

Tumor targeted Immunomodulation

Cancer Immunotherapy

Oncolytic Vectors

Reverse Genetic System

Recombinant Immunomodulatory Vectors

Measles Vaccine Vector

Bispecific T Cell Engager

Rozdziały w tym wideo

0:04

Title

0:47

Generation of Recombinant Virus Particles

2:47

Collection and Propagation of Virus Particles

5:11

Viral Titer Evaluation

6:59

Determining Replicative and Cytotoxic Capacities of Viral Vectors Encoding Immunomodulators

8:03

Assessment of Immunological Functionality of Isolated Virus-encoded Immunomodulators from Infected Cells

10:00

Results: Evaluation of Tumor-targeted Immunomodulation by Paramyxoviruses

11:37

Conclusion

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