A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Goal of this research is to use computational modeling to study the effect of local radiofrequency thermal intervention on the biomechanics of the tumor. We would be focusing particular on high intratumoral pressure driven by abnormal blood flow within the tumor, which is one of the main barriers to the effective distribution of therapeutic agents. Interventions such as radiofrequency hyperthermia have been recently explored as a potential tool to perturb a tumor microenvironment, for example, increasing blood flow and thereby decreasing intratumoral pressure.

This may lead to more favorable conditions to the distribution of therapeutic agents and potentially improve the patient's response to therapeutic treatments. Currently available to measure intratumoral pressure rely on invasive techniques that provide information, quantitative information, in only a few locations within the tumors. Computational model may provide the means to assess the special profile of biophysical variables across the entire tumor.

Protocol is the description of a computational workflow that captures the relationship between tissue temperature and blood perfusion driving changes in intratumoral pressure. The protocol describes a model geometry that in principle mirrors in-vivo experimental settings designed to approximate clinical thermal intervention. Perspective on how computational models can be employed to advance our understanding of how biophysical parameters of the tumor microenvironment, such as intratumoral pressure, can be affected by local thermal interventions.