Division of Gastroenterology,
Digestive Health Research Center
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Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure.
Gastroenterology Feb, 2002 | Pubmed ID: 11832463
A possible role of IL-1ra 3'-untranslated region in modulation of protein production.
Cytokine Jan, 2002 | Pubmed ID: 11886177
Effect of misoprostol on ibuprofen-induced renal dysfunction in patients with decompensated cirrhosis: results of a double-blind placebo-controlled parallel group study.
The American journal of gastroenterology Aug, 2002 | Pubmed ID: 12190173
Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2002 | Pubmed ID: 12391251
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
The Journal of experimental medicine Dec, 2002 | Pubmed ID: 12486099
Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis.
Gastroenterology Apr, 2003 | Pubmed ID: 12671894
Mouse models for the study of Crohn's disease.
Trends in molecular medicine May, 2003 | Pubmed ID: 12763527
TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2003 | Pubmed ID: 12832622
Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc.
Gastroenterology Aug, 2003 | Pubmed ID: 12891551
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2003 | Pubmed ID: 14568967
Future therapies for inflammatory bowel disease.
Current gastroenterology reports Dec, 2003 | Pubmed ID: 14602063
The Th1 immune pathway as a therapeutic target in Crohn's disease.
Current opinion in investigational drugs (London, England : 2000) Nov, 2003 | Pubmed ID: 14758766
Effect of digestive health care services integration on resource use and outcomes in patients with digestive disorders.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Mar, 2003 | Pubmed ID: 15017507
Optimal dosing of 5-aminosalicylic acid: 5 decades of choosing between politicians.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Jan, 2003 | Pubmed ID: 15017510
Differential contribution of IL-1Ra isoforms to allele-specific IL-1Ra mRNA accumulation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Apr, 2004 | Pubmed ID: 15144571
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease.
The Journal of clinical investigation Aug, 2004 | Pubmed ID: 15286805
Cytokine-based therapies for Crohn's disease--new paradigms.
The New England journal of medicine Nov, 2004 | Pubmed ID: 15537904
Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease.
Gastroenterology Feb, 2005 | Pubmed ID: 15685547
L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15699171
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation.
Gastroenterology Mar, 2005 | Pubmed ID: 15765401
Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice.
The American journal of pathology Apr, 2005 | Pubmed ID: 15793286
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease.
Gastroenterology Jul, 2005 | Pubmed ID: 16012931
New concepts in the pathophysiology of inflammatory bowel disease.
Annals of internal medicine Dec, 2005 | Pubmed ID: 16365470
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease.
Gastroenterology Jan, 2006 | Pubmed ID: 16401463
The primary defect in experimental ileitis originates from a nonhematopoietic source.
The Journal of experimental medicine Mar, 2006 | Pubmed ID: 16505137
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis.
The Journal of experimental medicine Apr, 2006 | Pubmed ID: 16567389
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.
Proceedings of the National Academy of Sciences of the United States of America May, 2006 | Pubmed ID: 16698931
Novel strategies to attenuate immune activation in Crohn's disease.
Current opinion in pharmacology Aug, 2006 | Pubmed ID: 16753341
Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Sep, 2006 | Pubmed ID: 16829206
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
The Journal of clinical investigation Nov, 2006 | Pubmed ID: 17024245
Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis.
Gastroenterology Nov, 2006 | Pubmed ID: 17101325
Cytokine therapy for Crohn's disease: advances in translational research.
Annual review of medicine , 2007 | Pubmed ID: 17217333
Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2007 | Pubmed ID: 17237431
The attrition of young physician-scientists: problems and potential solutions.
Gastroenterology Feb, 2007 | Pubmed ID: 17258744
Cloning IL-1 and the birth of a new era in cytokine biology.
Journal of immunology (Baltimore, Md. : 1950) May, 2007 | Pubmed ID: 17442919
Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force.
Gastroenterology May, 2007 | Pubmed ID: 17498517
Immunopathogenesis of inflammatory bowel disease: current concepts.
Current opinion in gastroenterology Jul, 2007 | Pubmed ID: 17545770
Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2007 | Pubmed ID: 17982092
MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.
American journal of physiology. Gastrointestinal and liver physiology Feb, 2008 | Pubmed ID: 18032482
A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2008 | Pubmed ID: 18250468
Early and late gut immune responses in IBD.
Journal of pediatric gastroenterology and nutrition Apr, 2008 | Pubmed ID: 18354325
Innate and adaptive immune responses related to IBD pathogenesis.
Current gastroenterology reports Dec, 2007 | Pubmed ID: 18377804
Commensal bacteria and "oncologic surveillance": suggestions from an experimental model.
Journal of clinical gastroenterology Sep, 2008 | Pubmed ID: 18685507
AGA Institute Future Trends Committee report: the future of gastroenterology training programs in the United States.
Gastroenterology Nov, 2008 | Pubmed ID: 19009690
Emerging drugs for the treatment of ulcerative colitis.
Expert opinion on emerging drugs Sep, 2009 | Pubmed ID: 19656075
Probiotics promote gut health through stimulation of epithelial innate immunity.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 20018654
Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2010 | Pubmed ID: 20926792
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis.
Inflammatory bowel diseases Dec, 2011 | Pubmed ID: 21557393
Spontaneous, immune-mediated gastric inflammation in SAMP1/YitFc mice, a model of Crohn's-like gastritis.
Gastroenterology Nov, 2011 | Pubmed ID: 21704001
A multicenter retrospective experience of infliximab in Crohn's disease patients: infusion reaction rates and treatment persistency.
Gastroenterology & hepatology May, 2007 | Pubmed ID: 21960854
New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation.
Cytokine Sep, 2012 | Pubmed ID: 22795953
Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism.
PloS one , 2012 | Pubmed ID: 22848704
Vercirnon for the treatment of Crohn's disease.
Expert opinion on investigational drugs Jul, 2013 | Pubmed ID: 23627683
RIP2 activity in inflammatory disease and implications for novel therapeutics.
Journal of leukocyte biology Jun, 2013 | Pubmed ID: 23794710
Inhibition of leukocyte trafficking in inflammatory bowel disease.
The New England journal of medicine Aug, 2013 | Pubmed ID: 23964940
Intestinal-Specific TNFα Overexpression Induces Crohn's-Like Ileitis in Mice.
PloS one , 2013 | Pubmed ID: 23977323
Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2013 | Pubmed ID: 24082103
The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation.
Current opinion in gastroenterology Nov, 2013 | Pubmed ID: 24100723
Functional defects in NOD2 signaling in experimental and human Crohn disease.
Gut microbes May-Jun, 2014 | Pubmed ID: 24637801
Inflammatory bowel disease.
Immunology letters Oct, 2014 | Pubmed ID: 24938525
Occurrence of spontaneous periodontal disease in the SAMP1/YitFc murine model of Crohn disease.
Journal of periodontology Dec, 2014 | Pubmed ID: 25019175
The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation.
Frontiers in immunology , 2014 | Pubmed ID: 25071778
Cytokines and mucosal immunity.
Current opinion in gastroenterology Nov, 2014 | Pubmed ID: 25203451
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25213858
Safety considerations when using anti-TNFα therapy to treat Crohn's disease.
Expert opinion on drug safety Jan, 2015 | Pubmed ID: 25400161
Ulcerative Colitis: What is the Optimal Treatment Goal and How Do We Achieve It?
Current treatment options in gastroenterology Mar, 2015 | Pubmed ID: 25619458
SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration.
Gastroenterology Apr, 2015 | Pubmed ID: 25620669
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Science (New York, N.Y.) Jun, 2015 | Pubmed ID: 26068857
Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes.
Nature communications Jul, 2015 | Pubmed ID: 26154811
Dysregulated intrahepatic CD4(+) T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice.
Cellular and molecular gastroenterology and hepatology Jul, 2015 | Pubmed ID: 26213712
Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.
Inflammatory bowel diseases Nov, 2015 | Pubmed ID: 26348447
Role of type 2 immunity in intestinal inflammation.
Current opinion in gastroenterology Nov, 2015 | Pubmed ID: 26376478
Pathway-based approaches to the treatment of inflammatory bowel disease.
Translational research : the journal of laboratory and clinical medicine Jan, 2016 | Pubmed ID: 26408803
IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.
The American journal of pathology Apr, 2016 | Pubmed ID: 26908008
Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations?
Gastroenterology Apr, 2016 | Pubmed ID: 26924087
A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2016 | Pubmed ID: 27233964
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease.
Frontiers in immunology , 2016 | Pubmed ID: 27531998
Clinical Effects of Gamma-Radiation-Resistant Aspergillus sydowii on Germ-Free Mice Immunologically Prone to Inflammatory Bowel Disease.
Journal of pathogens , 2016 | Pubmed ID: 27630775
Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis.
Cancer research Nov, 2016 | Pubmed ID: 27634763
Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.
Gastroenterology Jan, 2017 | Pubmed ID: 27639802
Cytokines and intestinal inflammation.
Current opinion in gastroenterology Nov, 2016 | Pubmed ID: 27673380
Our Vision for the Future of Inflammatory Bowel Diseases: Research, Innovations, and Controversies.
Inflammatory bowel diseases Jan, 2017 | Pubmed ID: 28002124
Mesenchymal stem/stromal cell therapy for inflammatory bowel disease: an updated review with maintenance of remission.
Current opinion in gastroenterology Jan, 2017 | Pubmed ID: 28134690
Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis.
Inflammatory bowel diseases Mar, 2017 | Pubmed ID: 28146004
A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis.
PloS one , 2017 | Pubmed ID: 28301579
Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model?
Cellular and molecular gastroenterology and hepatology Jul, 2017 | Pubmed ID: 28560286
A guiding map for inflammation.
Nature immunology Jul, 2017 | Pubmed ID: 28722720
Maneesh Dave1,
Paola Menghini1,
Keiki Sugi2,3,
Rodrigo A. Somoza5,
Zhenghong Lee4,
Mukesh Jain2,3,
Arnold Caplan5,
Fabio Cominelli1
1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University,
2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University,
3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center,
4Department of Radiology, University Hospitals Case Medical Center,
5Department of Biology - Skeletal Research Center, Case Western Reserve University
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