Tony Velkov

Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry.

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase.

Photoaffinity labeling of the N-methyltransferase domains of cyclosporin synthetase.

Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors--Cyclosporin synthetase as a complex example.

The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli.

An improved purification procedure for cyclosporin synthetase.

Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF.

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA.

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography.

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis.

Ni2+-based immobilized metal ion affinity chromatography of lactose operon repressor protein from Escherichia coli.

Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein.

Thermodynamics of lipophilic drug binding to intestinal fatty acid binding protein and permeation across membranes.

Probing the fibrate binding specificity of rat liver fatty acid binding protein.

Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.

Structure--activity relationships of polymyxin antibiotics.

Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization.

Developing an anion host for lipid A binding and antibacterial activity.

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions.

Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase.

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model.

Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1.

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies.

Head and flagella subcompartmental proteomic analysis of human spermatozoa.

Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

Molecular Characterization of Lipopolysaccharide Binding to Human α-1-Acid Glycoprotein.

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs.

Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats.

Polymyxin B induces apoptosis in kidney proximal tubular cells.

Interaction of phthalates and phenoxy acid herbicide environmental pollutants with intestinal intracellular lipid binding proteins.

PK/PD models in antibacterial development.

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.

The antigenic architecture of the hemagglutinin of influenza H5N1 viruses.

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

The RNA-dependent-RNA polymerase, an emerging antiviral drug target for the Hendra virus.

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity.

Nanoscale focused ion beam tomography of single bacterial cells for assessment of antibiotic effects.

Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria.

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site.

Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?

In situ probing the interior of single bacterial cells at nanometer scale.

Imaging the distribution of polymyxins in the kidney.

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway.

Analysis of Protein Thiol Changes Occurring During Rat Sperm Epididymal Maturation.

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats.

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach.

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells.

Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function.

Drug-drug plasma protein binding interactions of ivacaftor.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner.

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus.

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes.

Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses.

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii.

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe.

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii.

Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity.

Pharmacokinetics of levobupivacaine following infant spinal anesthesia.

Polymyxins: a new hope in combating Gram-negative superbugs?

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus.

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.

A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection.

An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI.

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes.

Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs'.

The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions.

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility.

Development of HPLC and LC-MS/MS methods for the analysis of ivacaftor, its major metabolites and lumacaftor in plasma and sputum of cystic fibrosis patients treated with ORKAMBI or KALYDECO.

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators.

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin.

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria.

Rediscovering the octapeptins.

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress.

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii.

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs.

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility.

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization.

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

Polymyxins for CNS infections: Pharmacology and neurotoxicity.

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response.

Aminoglycoside concentrations required for synergy with carbapenems against Pseudomonas aeruginosa determined via mechanistic studies and modeling.

Gelofusine ameliorates colistin-induced nephrotoxicity.

Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

Design and Evaluation of Novel Polymyxin Fluorescent Probes.

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens.

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules.

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa.

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens.

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant : A Metabolomic Study.

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates.

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains.

Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers.

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant .

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms.

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR .

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae.

Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections.

Global Metabolic Analyses of Acinetobacter baumannii.

The rise and spread of plasmid-mediated polymyxin resistance.

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant .

Polymyxins: Mode of Action.

Mechanisms of Polymyxin-Induced Nephrotoxicity.

Discovery of Novel Polymyxin-Like Antibiotics.

Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.

The impact of backbone N-methylation on the structure-activity relationship of Leu -teixobactin.

T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction.

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform.

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa.

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant .

DNA variants are an unlikely explanation for the changing quality of spermatozoa within the same individual.

Synthesis and structure-activity relationships of teixobactin.

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections.

Structure of micelle bound cationic peptides by NMR spectroscopy using a lanthanide shift reagent.

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice.

Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606.

Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB.

Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae.

Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity.

Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study.

Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment.

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways.

The Antimicrobial Activity of Cannabinoids.

Structure-Activity Relationships of Daptomycin Lipopeptides.

Lipid A profiling and metabolomics analysis of paired polymyxin-susceptible and -resistant MDR Klebsiella pneumoniae clinical isolates from the same patients before and after colistin treatment.

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency.

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens.

In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model.

Evaluation Strategies for Triple-Drug Combinations against Carbapenemase-Producing Klebsiella Pneumoniae in an In Vitro Hollow-Fiber Infection Model.

Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells.

Polymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomes.

Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Is Predominately Driven by Chloramphenicol.

Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant and Minimize Biofilm Formation.

Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.

A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.

Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis.

Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane.

Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant by a bacteriophage-polymyxin combination.

p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling.

Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant .

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems.

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.

An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates.

Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.

Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against : A Metabolomic Study.

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity.

T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications.