Jeffrey D. Rothstein

The development of excitatory synapses in cultured spinal neurons.

Glutamate transporter protein subtypes are expressed differentially during rat CNS development.

Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain.

Mechanisms for reversible regulation between G13 and Rho exchange factors.

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.

A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy.

Paving new pathways.

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis.

Therapeutic developments in the treatment of amyotrophic lateral sclerosis.

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.

Aggregate formation in Cu,Zn superoxide dismutase-related proteins.

Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice.

Of mice and men: reconciling preclinical ALS mouse studies and human clinical trials.

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.

Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.

Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells.

Glutamate transporter expression and function in human glial progenitors.

Reality and immortality--neural stem cells for therapies.

Altered expression of the glutamate transporter EAAT2b in neurological disease.

Glutamate receptor antagonists protect from virus-induced neural degeneration.

Glutamate transporters: animal models to neurologic disease.

Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1 [correction].

Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats.

Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.

Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.

Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.

Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors.

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro.

Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly.

Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.

Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS.

Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection.

Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis.

Spectrin mutations cause spinocerebellar ataxia type 5.

Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity.

Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype.

Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.

Trial of celecoxib in amyotrophic lateral sclerosis.

Recovery from paralysis in adult rats using embryonic stem cells.

The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea.

Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis.

Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus.

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.

Mechanisms of Disease: astrocytes in neurodegenerative disease.

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.

Targeting an old mechanism in a new disease-protection of glutamatergic dysfunction in depression.

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS.

TDP-43 in amyotrophic lateral sclerosis: pathophysiology or patho-babel?

Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS.

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS.

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein.

Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking.

Models of amyotrophic lateral sclerosis.

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease.

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.

Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1.

Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis.

Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve.

Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.

A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis.

GLT-1 Promoter Activity in Astrocytes and Neurons of Mouse Hippocampus and Somatic Sensory Cortex.

Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex.

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum.

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression.

Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice.

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

New treatments in amyotrophic lateral sclerosis.

Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.

John W. "Jack" Griffin, MD.

Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes.

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

Plasticity of astroglial networks in olfactory glomeruli.

Neuronal activity regulates glutamate transporter dynamics in developing astrocytes.

β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis.

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.

Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies.

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study.

C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC.

Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction.

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.

Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model.

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

3D Printer Generated Tissue iMolds for Cleared Tissue Using Single- and Multi-Photon Microscopy for Deep Tissue Evaluation.

Edaravone: A new drug approved for ALS.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis.

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin.

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.

Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging.

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.

Astrocyte Diversity: Current Insights and Future Directions.

arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import.

Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities.

GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration.

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Reactive astrocyte nomenclature, definitions, and future directions.

Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.

A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation.

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei.

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.

RNA Is a Double-Edged Sword in ALS Pathogenesis.

Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD.