in-vivo-assessment-rodent-plasmodium-parasitemia-merozoite-invasion

<em>In Vivo</em> Assessment of Rodent <em>Plasmodium</em> Parasitemia and Merozoite Invasion by Flow Cytometry

During blood stage infection, malaria parasites invade, mature, and replicate within red blood cells (RBCs). This results in a regular growth cycle and an ...

Macquarie University

Malaria treatments are becoming less effective due to the rapid spread of drug resistant parasites. Increased understanding of the host/parasite interaction is crucial in order to develop treatments that will be less prone to resistance. Parasite invasion of the red blood cell (RBC) is a critical aspect of the parasite life cycle and is, therefore, a promising target for the development of malaria treatments. Assays for analysing parasite invasion in vitro have been developed, but no equivalent assays exist for in vivo studies. This article describes a novel flow cytometric in vivo parasite invasion assay.

Patrick M. Lelliott

Australian School of Advanced Medicine

Macquarie University

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry

Patrick M. Lelliott

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Australian School of Advanced Medicine

Macquarie University

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry

Australian School of Advanced Medicine