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Simulation of cholinesterase status at different scenarios of nerve agent exposure.
Toxicology Apr, 2007 | Pubmed ID: 16904807
Development of antidotes: problems and strategies.
Toxicology Apr, 2007 | Pubmed ID: 16949190
The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices.
Toxicology Mar, 2003 | Pubmed ID: 12499118
Human parathion poisoning. A toxicokinetic analysis.
Toxicological reviews , 2003 | Pubmed ID: 15181664
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.
Biochemical pharmacology Dec, 2004 | Pubmed ID: 15498514
Ketamine reduces cholinergic modulated GABA release from rat striatal slices.
Toxicology letters Apr, 2005 | Pubmed ID: 15763635
Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model.
Toxicology and applied pharmacology Dec, 2005 | Pubmed ID: 15904945
Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon.
Toxicology Oct, 2005 | Pubmed ID: 16040183
Diagnostic aspects of organophosphate poisoning.
Toxicology Oct, 2005 | Pubmed ID: 16051411
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning.
Chemico-biological interactions Dec, 2005 | Pubmed ID: 16263103
Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach.
Chemico-biological interactions Dec, 2005 | Pubmed ID: 16266695
Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality.
Toxicology Apr, 2007 | Pubmed ID: 17010492
Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro.
Toxicology Apr, 2007 | Pubmed ID: 17030394
Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning.
Toxicology Apr, 2007 | Pubmed ID: 17161895
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
Biochemical pharmacology Jun, 2007 | Pubmed ID: 17382909
Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro.
Anesthesiology Jun, 2007 | Pubmed ID: 17525590
Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Nov, 2007 | Pubmed ID: 17888747
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.
Arhiv za higijenu rada i toksikologiju Sep, 2007 | Pubmed ID: 17913691
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Biochemical pharmacology Feb, 2008 | Pubmed ID: 17977518
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors.
Toxicology Apr, 2008 | Pubmed ID: 18304715
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning.
Analytical and bioanalytical chemistry May, 2008 | Pubmed ID: 18330546
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Biochemistry May, 2008 | Pubmed ID: 18396898
Sulfur mustard research--strategies for the development of improved medical therapy.
Eplasty , 2008 | Pubmed ID: 18615149
Are we using the right dose? - a tale of mole and gram.
British journal of clinical pharmacology Oct, 2008 | Pubmed ID: 18662291
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep, 2008 | Pubmed ID: 18718824
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
The Biochemical journal Jul, 2009 | Pubmed ID: 19368529
Clinical picture of sulfur mustard poisoning.
Toxicology Sep, 2009 | Pubmed ID: 19386280
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Toxicology Apr, 2009 | Pubmed ID: 19428926
Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology Sep, 2009 | Pubmed ID: 19433070
The chronic effects of sulfur mustard exposure.
Toxicology Sep, 2009 | Pubmed ID: 19486919
Plasma level of atropine after accidental ingestion of Atropa belladonna.
Clinical toxicology (Philadelphia, Pa.) Jul, 2009 | Pubmed ID: 19586361
Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May, 2010 | Pubmed ID: 19766064
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
Clinical toxicology (Philadelphia, Pa.) Sep, 2009 | Pubmed ID: 19778163
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
Clinical toxicology (Philadelphia, Pa.) Sep, 2009 | Pubmed ID: 19778190
Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients.
Toxicology letters Dec, 2009 | Pubmed ID: 19793545
LC-ESI MS/MS quantification of atropine and six other antimuscarinic tropane alkaloids in plasma.
Analytical and bioanalytical chemistry Jan, 2010 | Pubmed ID: 19855962
Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning.
Chemico-biological interactions Sep, 2010 | Pubmed ID: 19883634
Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations.
Chemico-biological interactions Sep, 2010 | Pubmed ID: 19917271
The toxicokinetics and toxicodynamics of organophosphonates versus the pharmacokinetics and pharmacodynamics of oxime antidotes: biological consequences.
Basic & clinical pharmacology & toxicology Feb, 2010 | Pubmed ID: 19961476
Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation.
Toxicology Jan, 2010 | Pubmed ID: 20004696
Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds.
Chemico-biological interactions Sep, 2010 | Pubmed ID: 20036651
GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May, 2010 | Pubmed ID: 20061191
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
Chemico-biological interactions Sep, 2010 | Pubmed ID: 20105433
Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May, 2010 | Pubmed ID: 20106727
Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon.
Toxicology letters May, 2010 | Pubmed ID: 20156534
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
Toxicology Jun, 2010 | Pubmed ID: 20385200
Bioanalysis of organophosphorus toxicants and corresponding antidotes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May, 2010 | Pubmed ID: 20395180
Side-specific effects by cadmium exposure: apical and basolateral treatment in a coculture model of the blood-air barrier.
Toxicology and applied pharmacology Jun, 2010 | Pubmed ID: 20399800
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.
Biochemical pharmacology Sep, 2010 | Pubmed ID: 20510679
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.
Toxicology letters Sep, 2010 | Pubmed ID: 20542100
Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis.
Toxicology letters Oct, 2010 | Pubmed ID: 20696220
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.
Analytical and bioanalytical chemistry Nov, 2010 | Pubmed ID: 20730528
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach.
Journal of enzyme inhibition and medicinal chemistry Jun, 2011 | Pubmed ID: 20807085
Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation.
Toxicological sciences : an official journal of the Society of Toxicology Dec, 2010 | Pubmed ID: 20833707
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach.
Toxicology and applied pharmacology Dec, 2010 | Pubmed ID: 20888357
High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma.
Analytica chimica acta Nov, 2010 | Pubmed ID: 20969988
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
Toxicology letters Jan, 2011 | Pubmed ID: 20971170
In vitro detoxification of cyclosarin (GF) by modified cyclodextrins.
Toxicology letters Jan, 2011 | Pubmed ID: 21035528
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases.
Chemico-biological interactions Apr, 2011 | Pubmed ID: 21354413
Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species.
Toxicology mechanisms and methods Sep, 2011 | Pubmed ID: 21470076
Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution.
Cells, tissues, organs , 2011 | Pubmed ID: 21494014
Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue.
Toxicology letters Sep, 2011 | Pubmed ID: 21530620
Thirteenth International Medical Chemical Defence Conference 2011 "New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents".
Toxicology letters Sep, 2011 | Pubmed ID: 21605643
Anaesthetic potency of diazepam is resistant to cholinergic overstimulation.
Toxicology letters Sep, 2011 | Pubmed ID: 21699965
Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning.
Toxicology letters Sep, 2011 | Pubmed ID: 21771644
Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep, 2011 | Pubmed ID: 21862421
Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis.
Chemico-biological interactions Nov, 2011 | Pubmed ID: 21930118
Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.
Drug testing and analysis Mar-Apr, 2012 | Pubmed ID: 21964777
Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning.
Drug testing and analysis Mar-Apr, 2012 | Pubmed ID: 21998030
Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning.
Annals of emergency medicine Dec, 2011 | Pubmed ID: 22098995
Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig.
Drug testing and analysis Mar-Apr, 2012 | Pubmed ID: 22102522
In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase).
Drug testing and analysis Mar-Apr, 2012 | Pubmed ID: 22174192
Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase.
Toxicology letters Mar, 2012 | Pubmed ID: 22230262
A role for solvents in the toxicity of agricultural organophosphorus pesticides.
Toxicology Apr, 2012 | Pubmed ID: 22365945
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
Archives of toxicology Sep, 2012 | Pubmed ID: 22437842
Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase.
Toxicology letters Jul, 2012 | Pubmed ID: 22561105
Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships.
Biochemical pharmacology Jun, 2012 | Pubmed ID: 22649796
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Chemico-biological interactions Mar, 2013 | Pubmed ID: 22827894
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.
Toxicology Dec, 2012 | Pubmed ID: 22982866
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.
Toxicology letters Feb, 2013 | Pubmed ID: 23201438
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.
Toxicology letters Feb, 2013 | Pubmed ID: 23201439
The value of novel oximes for treatment of poisoning by organophosphorus compounds.
Pharmacology & therapeutics Aug, 2013 | Pubmed ID: 23603539
Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23669118
Organophosphate poisoning in the developed world - a single centre experience from here to the millennium.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23685200
Silibinin as a potential therapeutic for sulfur mustard injuries.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23810508
Sulfur mustard induced nuclear translocation of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH).
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23827652
Effects of succinylcholine in an organotypic spinal cord-skeletal muscle coculture of embryonic mice.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23838346
Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic aspects.
Toxicology letters Oct, 2013 | Pubmed ID: 23906718
Fourteenth International Medical Chemical Defence Conference 2013 "Translation of experimental research for improved treatment of chemical warfare agents".
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23920049
Modified immunoslotblot assay to detect hemi and sulfur mustard DNA adducts.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23933409
Mesenchymal stem cells are highly resistant to sulfur mustard.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23933411
Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23962483
Influence of organophosphate poisoning on human dendritic cells.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 23994500
Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells.
Chemico-biological interactions Aug, 2013 | Pubmed ID: 23994502
Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.
Toxicological sciences : an official journal of the Society of Toxicology Dec, 2013 | Pubmed ID: 24052565
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).
Archives of toxicology Feb, 2014 | Pubmed ID: 24057572
Limitations and challenges in treatment of acute chemical warfare agent poisoning.
Chemico-biological interactions Dec, 2013 | Pubmed ID: 24091052
Drug development for the management of organophosphorus poisoning.
Expert opinion on drug discovery Dec, 2013 | Pubmed ID: 24125474
Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin--an in vitro structure-activity study.
Toxicology letters Jan, 2014 | Pubmed ID: 24185128
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.
Archives of toxicology Jun, 2014 | Pubmed ID: 24477626
Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo.
Toxicology letters Apr, 2014 | Pubmed ID: 24561299
In vitro toxicokinetic studies of cyclosarin: molecular mechanisms of elimination.
Toxicology letters May, 2014 | Pubmed ID: 24641973
V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond.
Analytical and bioanalytical chemistry Aug, 2014 | Pubmed ID: 24652148
Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - effects of α-linolenic acid and N-acetylcysteine.
Chemico-biological interactions Aug, 2014 | Pubmed ID: 24892517
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase.
Archives of toxicology Mar, 2015 | Pubmed ID: 24912784
Spinal cord--skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A.
ALTEX , 2014 | Pubmed ID: 25127438
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.
Toxicology letters Nov, 2014 | Pubmed ID: 25195526
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.
Toxicology letters Nov, 2014 | Pubmed ID: 25240274
Development of a co-culture of keratinocytes and immune cells for in vitro investigation of cutaneous sulfur mustard toxicity.
Chemico-biological interactions Sep, 2014 | Pubmed ID: 25256379
Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agents.
Archives of toxicology Nov, 2014 | Pubmed ID: 25395009
In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects.
Toxicology letters Jan, 2015 | Pubmed ID: 25448275
Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime.
Toxicology in vitro : an international journal published in association with BIBRA Feb, 2015 | Pubmed ID: 25450746
Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.
Toxicology letters Feb, 2015 | Pubmed ID: 25522658
Evidence of Sulfur Mustard Exposure in Human Plasma by LC-ESI-MS-MS Detection of the Albumin-Derived Alkylated HETE-CP Dipeptide and Chromatographic Investigation of Its Cis/Trans Isomerism.
Journal of analytical toxicology May, 2015 | Pubmed ID: 25712440
Small-scale purification of butyrylcholinesterase from human plasma and implementation of a μLC-UV/ESI MS/MS method to detect its organophosphorus adducts.
Drug testing and analysis Mar, 2015 | Pubmed ID: 25828536
Reversed-phase ion-pair chromatography-diode array detection of the bispyridinium compound MB327: plasma analysis of a potential novel antidote for the treatment of organophosphorus poisoning.
Drug testing and analysis Jun, 2015 | Pubmed ID: 26041012
Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor.
Archives of toxicology Jun, 2015 | Pubmed ID: 26082309
Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.
Toxicology letters Feb, 2016 | Pubmed ID: 26200596
Catalytic bioscavengers in nerve agent poisoning: A promising approach?
Toxicology letters Feb, 2016 | Pubmed ID: 26200600
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.
Toxicology letters Feb, 2016 | Pubmed ID: 26210933
Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro.
Toxicology letters Feb, 2016 | Pubmed ID: 26220518
Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures.
Toxicology letters Feb, 2016 | Pubmed ID: 26256036
Botulinum toxin B increases intrinsic muscle activity in organotypic spinal cord-skeletal muscle co-cultures.
Toxicology letters Feb, 2016 | Pubmed ID: 26260118
Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro.
Toxicology letters Nov, 2015 | Pubmed ID: 26272752
Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.
Toxicology letters Feb, 2016 | Pubmed ID: 26321678
Anesthetic actions of thiopental remain largely unaffected during cholinergic overstimulation in cultured cortical networks.
Toxicology letters Feb, 2016 | Pubmed ID: 26325215
Optimization of the CULTEX(®) radial flow system for in vitro investigation of lung damaging agents.
Toxicology letters Feb, 2016 | Pubmed ID: 26358518
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.
Toxicology letters Feb, 2016 | Pubmed ID: 26361990
Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes.
Toxicology in vitro : an international journal published in association with BIBRA Dec, 2015 | Pubmed ID: 26368669
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
Toxicology letters Feb, 2016 | Pubmed ID: 26383629
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.
Toxicology letters Feb, 2016 | Pubmed ID: 26383632
Epigenetic modulations in early endothelial cells and DNA hypermethylation in human skin after sulfur mustard exposure.
Toxicology letters Feb, 2016 | Pubmed ID: 26392148
Optimized verification method for detection of an albumin-sulfur mustard adduct at Cys(34) using a hybrid quadrupole time-of-flight tandem mass spectrometer after direct plasma proteolysis.
Toxicology letters Feb, 2016 | Pubmed ID: 26449527
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM.
Toxicology letters Feb, 2016 | Pubmed ID: 26456177
Alteration of miRNA expression in early endothelial cells after exposure with sub-lethal sulfur mustard concentrations.
Toxicology letters Feb, 2016 | Pubmed ID: 26456178
Development of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
Toxicology letters Feb, 2016 | Pubmed ID: 26463895
A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity.
Toxicology letters Feb, 2016 | Pubmed ID: 26494253
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Archives of toxicology Nov, 2016 | Pubmed ID: 26612364
Editorial.
Toxicology letters Feb, 2016 | Pubmed ID: 26873068
On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds.
Toxicology letters May, 2016 | Pubmed ID: 27033775
Oximes in organophosphate poisoning: 60 years of hope and despair.
Chemico-biological interactions Nov, 2016 | Pubmed ID: 27125761
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
Toxicology 03, 2016 | Pubmed ID: 27153754
Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum.
Toxicology in vitro : an international journal published in association with BIBRA Sep, 2016 | Pubmed ID: 27184650
Toxicology of organophosphorus compounds in view of an increasing terrorist threat.
Archives of toxicology Sep, 2016 | Pubmed ID: 27349770
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
Archives of toxicology Mar, 2017 | Pubmed ID: 27358236
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.
Toxicology letters Sep, 2016 | Pubmed ID: 27397758
Procedures for Analysis of Dried Plasma Using Microsampling Devices to Detect Sulfur Mustard-Albumin Adducts for Verification of Poisoning.
Analytical chemistry 09, 2016 | Pubmed ID: 27482832
Modification of human serum albumin by the nerve agent VX: microbore liquid chromatography/electrospray ionization high-resolution time-of-flight tandem mass spectrometry method for detection of phosphonylated tyrosine and novel cysteine containing disulfide adducts.
Rapid communications in mass spectrometry : RCM Oct, 2016 | Pubmed ID: 27490696
Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study.
Toxicology letters Nov, 2016 | Pubmed ID: 27639501
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.
Archives of toxicology May, 2017 | Pubmed ID: 27738742
S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA.
Chemico-biological interactions Jan, 2017 | Pubmed ID: 27923644
Identification of novel disulfide adducts between the thiol containing leaving group of the nerve agent VX and cysteine containing tripeptides derived from human serum albumin.
Drug testing and analysis Aug, 2017 | Pubmed ID: 27935238
Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.
Toxicology 08, 2017 | Pubmed ID: 28743514
Effects of sulfur mustard on mesenchymal stem cells.
Toxicology letters Sep, 2018 | Pubmed ID: 28818580
Alteration of miRNA expression in a sulfur mustard resistant cell line.
Toxicology letters Sep, 2018 | Pubmed ID: 28823541
Development of a sensitive, generic and easy to use organophosphate skin disclosure kit.
Toxicology letters Oct, 2017 | Pubmed ID: 28851585
N-Acetylcysteine as a chemical scavenger for sulfur mustard: New insights by mass spectrometry.
Drug testing and analysis Feb, 2018 | Pubmed ID: 28879668
Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models.
Toxicology letters Sep, 2018 | Pubmed ID: 28916287
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.
Toxicology letters Sep, 2018 | Pubmed ID: 28916288
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.
Toxicology letters Sep, 2018 | Pubmed ID: 28919489
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.
Archives of toxicology Jan, 2018 | Pubmed ID: 28932886
Environmental exposure to organophosphorus nerve agents.
Environmental toxicology and pharmacology Dec, 2017 | Pubmed ID: 28942081
The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study.
Toxicology letters Sep, 2018 | Pubmed ID: 28993240
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
Toxicology letters Sep, 2018 | Pubmed ID: 29097222
Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning.
Toxicology letters Sep, 2018 | Pubmed ID: 29154801
Sulfur mustard-induced epigenetic modifications over time - a pilot study.
Toxicology letters Sep, 2018 | Pubmed ID: 29155286
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.
Toxicology letters Sep, 2018 | Pubmed ID: 29183814
Accidental sulfur mustard exposure: A case report.
Toxicology letters Sep, 2018 | Pubmed ID: 29191789
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.
Toxicology letters Sep, 2018 | Pubmed ID: 29191791
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
Toxicology letters Sep, 2018 | Pubmed ID: 29248576
Glutathione as an antidote for sulfur mustard poisoning: Mass spectrometric investigations of its potency as a chemical scavenger.
Toxicology letters Sep, 2018 | Pubmed ID: 29277572
Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin.
Analytical and bioanalytical chemistry Feb, 2018 | Pubmed ID: 29322229
Mobilization of human mesenchymal stem cells through different cytokines and growth factors after their immobilization by sulfur mustard.
Toxicology letters Sep, 2018 | Pubmed ID: 29426001
Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
Toxicology letters Sep, 2018 | Pubmed ID: 29551593
A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning.
Toxicology letters Aug, 2018 | Pubmed ID: 29702198
Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl.
Toxicology letters Sep, 2018 | Pubmed ID: 29777832
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
Current computer-aided drug design , 2019 | Pubmed ID: 29968541
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
ChemMedChem 09, 2018 | Pubmed ID: 29974635
Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass spectrometry.
Rapid communications in mass spectrometry : RCM Nov, 2018 | Pubmed ID: 30117208
Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman.
Toxicology letters Nov, 2018 | Pubmed ID: 30165091
Verification of organophosphorus pesticide poisoning: Detection of phosphorylated tyrosines and a cysteine-proline disulfide-adduct from human serum albumin after intoxication with dimethoate/omethoate.
Toxicology letters Dec, 2018 | Pubmed ID: 30165092
Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 () In Vitro.
Cells Aug, 2018 | Pubmed ID: 30200301
Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats.
Clinical toxicology (Philadelphia, Pa.) 05, 2019 | Pubmed ID: 30307341
Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.
Toxicology letters Dec, 2018 | Pubmed ID: 30312685
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
ChemMedChem 12, 2018 | Pubmed ID: 30362667
Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.
Chemico-biological interactions Jan, 2019 | Pubmed ID: 30391637
Collision-induced mass spectrometric fragmentation of protonated dimethoate and omethoate generated by electrospray ionization.
Rapid communications in mass spectrometry : RCM Feb, 2019 | Pubmed ID: 30402977
Methionine in human serum albumin: A novel target for alkylation by sulfur mustard.
Drug testing and analysis May, 2019 | Pubmed ID: 30468304
A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.
Chemico-biological interactions Jan, 2019 | Pubmed ID: 30502332
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning.
Clinical toxicology (Philadelphia, Pa.) Jul, 2019 | Pubmed ID: 30696282
Human small bowel as model for poisoning with organophosphorus compounds.
Toxicology in vitro : an international journal published in association with BIBRA Jun, 2019 | Pubmed ID: 30763608
The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM).
Toxicology letters Jun, 2019 | Pubmed ID: 30858091
Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.
Toxicology in vitro : an international journal published in association with BIBRA Aug, 2019 | Pubmed ID: 30890356
Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.
Toxicology letters Sep, 2019 | Pubmed ID: 31048000
Forensic evidence of sulfur mustard exposure in real cases of human poisoning by detection of diverse albumin-derived protein adducts.
Archives of toxicology 07, 2019 | Pubmed ID: 31069408
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
Toxicology letters Oct, 2019 | Pubmed ID: 31404593
Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning.
Clinical toxicology (Philadelphia, Pa.) Aug, 2019 | Pubmed ID: 31452424
Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.
Archives of toxicology Nov, 2019 | Pubmed ID: 31515601
[Chemical warfare agent poisoning].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Nov, 2019 | Pubmed ID: 31602511
Effect of sulfur mustard on melanogenesis in vitro.
Toxicology letters Feb, 2020 | Pubmed ID: 31785464
Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by P-NMR spectroscopy.
Toxicology letters Mar, 2020 | Pubmed ID: 31805340
Validation of automated pipetting systems for cell culture seeding, exposure and bio-analytical assays in sulfur mustard toxicology.
Toxicology letters Mar, 2020 | Pubmed ID: 31809884
Comparison of the toxicity of sulfur mustard and its oxidation products in vitro.
Toxicology letters Mar, 2020 | Pubmed ID: 31863871
Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks.
Toxicology letters Apr, 2020 | Pubmed ID: 31954869
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