Scott J. Hultgren

Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli.

Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD.

Role of Escherichia coli curli operons in directing amyloid fiber formation.

Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli.

Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.

Innate defense evicts bacterial squatters.

Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli.

Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin.

Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis.

Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria.

Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation.

Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli.

Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract.

CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli.

Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli.

Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly.

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides.

Intracellular bacterial biofilm-like pods in urinary tract infections.

Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria.

Targeting virulence for antimicrobial chemotherapy.

Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis.

Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.

The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.

Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.

P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli.

Structural biology: anthrax hijacks host receptor.

Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis.

Host subversion by formation of intracellular bacterial communities in the urinary tract.

Fiber assembly by the chaperone-usher pathway.

Catalysis of protein folding by chaperones in pathogenic bacteria.

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.

Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors.

Interaction of uropathogenic Escherichia coli with host uroepithelium.

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli.

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.

Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.

Blueprinting the regulatory response of Escherichia coli to the urinary tract.

Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli.

Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization.

Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli.

NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.

The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP.

A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase.

Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein.

LRP6 holds the key to the entry of anthrax toxin.

Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.

Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.

Maturation of intracellular Escherichia coli communities requires SurA.

Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli.

Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract.

Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation.

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

Filamentation by Escherichia coli subverts innate defenses during urinary tract infection.

Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.

Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.

Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli.

Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled.

Crystal structure of the P pilus rod subunit PapA.

Sticky fibers and uropathogenesis: bacterial adhesins in the urinary tract.

LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.

The biology and future prospects of antivirulence therapies.

Detection of intracellular bacterial communities in human urinary tract infection.

Morphological plasticity as a bacterial survival strategy.

Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression.

Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.

Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.

Streptozocin-induced diabetic mouse model of urinary tract infection.

G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.

Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF.

Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli.

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.

Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.

Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development.

A murine model of urinary tract infection.

QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.

Structural biology of the chaperone-usher pathway of pilus biogenesis.

Bacterial adhesion--a source of alternate antibiotic targets.

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.

Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding.

Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis.

Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis.

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.

The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili.

A tale of two pili: assembly and function of pili in bacteria.

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.

Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections.

Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.

Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli.

Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity.

A central metabolic circuit controlled by QseC in pathogenic Escherichia coli.

Antitoxins: therapy for stressed bacteria.

Update on biofilm infections in the urinary tract.

Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.

CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation.

Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection.

Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection.

Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?

Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.

Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection.

Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms.

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.

The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.

What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli.

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.

Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli.

Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific.

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.

Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics.

Dissection of pilus tip assembly by the FimD usher monomer.

Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes.

AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis.

The complex interactions of bacterial pathogens and host defenses.

Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Structural and energetic basis of folded-protein transport by the FimD usher.

Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection.

A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131.

Estrogen and recurrent UTI: what are the facts?

From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections.

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.

Escherichia coli biofilms have an organized and complex extracellular matrix structure.

Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

Molecular basis of usher pore gating in Escherichia coli pilus biogenesis.

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG.

EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.

Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection.

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.

Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection.

Chaos controlled: discovery of a powerful amyloid inhibitor.

Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice.

Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection.

Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity.

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.

Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice.

The pilus usher controls protein interactions via domain masking and is functional as an oligomer.