Brandenburg Center for Regenerative Therapies
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Three-dimensional co-culture of primary human liver cells in bioreactors for in vitro drug studies: effects of the initial cell quality on the long-term maintenance of hepatocyte-specific functions.
Alternatives to laboratory animals : ATLA Sep-Oct, 2002 | Pubmed ID: 12405881
Recovery of preservation-injured primary human hepatocytes and nonparenchymal cells to tissuelike structures in large-scale bioreactors for liver support: an initial transmission electron microscopy study.
Journal of investigative surgery : the official journal of the Academy of Surgical Research Mar-Apr, 2003 | Pubmed ID: 12746191
Porcine endogenous retroviruses: no infection in patients treated with a bioreactor based on porcine liver cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Oct, 2003 | Pubmed ID: 12957184
Extracorporeal liver support based on primary human liver cells and albumin dialysis--treatment of a patient with primary graft non-function.
Journal of hepatology Oct, 2003 | Pubmed ID: 12971979
Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study.
Transplantation Sep, 2003 | Pubmed ID: 14501853
Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study.
Tissue engineering Jul-Aug, 2004 | Pubmed ID: 15363168
Evaluation of primary human liver cells in bioreactor cultures for extracorporeal liver support on the basis of urea production.
Artificial organs Sep, 2006 | Pubmed ID: 16934097
Bioartificial liver systems: why, what, whither?
Regenerative medicine Jul, 2008 | Pubmed ID: 18588477
Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.
Cytotechnology Jul, 2008 | Pubmed ID: 19003182
Isolation and characterization of adult human liver progenitors from ischemic liver tissue derived from therapeutic hepatectomies.
Tissue engineering. Part A Jul, 2009 | Pubmed ID: 19108677
Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support.
Biotechnology and bioengineering Jul, 2009 | Pubmed ID: 19274748
Dynamic 3D culture promotes spontaneous embryonic stem cell differentiation in vitro.
Tissue engineering. Part C, Methods Feb, 2010 | Pubmed ID: 19382830
The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end.
Stem cell research Sep-Nov, 2009 | Pubmed ID: 19520631
Molecular characterization of cultured adult human liver progenitor cells.
Tissue engineering. Part C, Methods Oct, 2010 | Pubmed ID: 19874131
Three-dimensional perfusion bioreactor culture supports differentiation of human fetal liver cells.
Tissue engineering. Part A Jun, 2010 | Pubmed ID: 20088704
Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture.
Cells, tissues, organs , 2010 | Pubmed ID: 20197653
Lidocaine/monoethylglycinexylidide test, galactose elimination test, and sorbitol elimination test for metabolic assessment of liver cell bioreactors.
Artificial organs Jun, 2010 | Pubmed ID: 20456323
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.
Journal of pharmacological and toxicological methods Jan-Feb, 2011 | Pubmed ID: 20460162
Feasibility of using sodium chloride as a tracer for the characterization of the distribution of matter in complex multi-compartment 3D bioreactors for stem cell culture.
The International journal of artificial organs Jun, 2010 | Pubmed ID: 20669145
Optimization of a serum-free culture medium for mouse embryonic stem cells using design of experiments (DoE) methodology.
Cytotechnology Dec, 2010 | Pubmed ID: 20859764
Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.
Tissue engineering. Part C, Methods May, 2011 | Pubmed ID: 21210724
Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.
Drug metabolism and disposition: the biological fate of chemicals Jul, 2011 | Pubmed ID: 21436404
In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.
Journal of tissue engineering and regenerative medicine Aug, 2011 | Pubmed ID: 21442764
Cell therapeutic options in liver diseases: cell types, medical devices and regulatory issues.
Journal of materials science. Materials in medicine May, 2011 | Pubmed ID: 21461918
Perfusion circuit concepts for hollow-fiber bioreactors used as in vitro cell production systems or ex vivo bioartificial organs.
The International journal of artificial organs May, 2011 | Pubmed ID: 21623585
Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
Alternatives to laboratory animals : ATLA May, 2011 | Pubmed ID: 21639679
Compartmental hollow fiber capillary membrane-based bioreactor technology for in vitro studies on red blood cell lineage direction of hematopoietic stem cells.
Tissue engineering. Part C, Methods Feb, 2012 | Pubmed ID: 21933020
Active wound dressing with artificial capillaries for temporary wound irrigation and skin cell supply.
Artificial organs Apr, 2012 | Pubmed ID: 22074237
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.
Biotechnology and bioengineering Dec, 2012 | Pubmed ID: 22688505
Phenotypical characterization of 6-21-week gestational age human dermis and epidermal cell isolation methods for in vitro studies on epidermal progenitors.
Burns : journal of the International Society for Burn Injuries Mar, 2013 | Pubmed ID: 22749444
Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.
Journal of tissue engineering and regenerative medicine Nov, 2012 | Pubmed ID: 23165723
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
ALTEX , 2014 | Pubmed ID: 25027500
Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells.
Experimental biology and medicine (Maywood, N.J.) May, 2015 | Pubmed ID: 25394621
Feasibility study of an active wound dressing based on hollow fiber membranes in a porcine wound model.
Burns : journal of the International Society for Burn Injuries Jun, 2015 | Pubmed ID: 25451146
Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor.
Biotechnology progress Jan, 2016 | Pubmed ID: 26486457
Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI.
Mediators of inflammation , 2015 | Pubmed ID: 26491234
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