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N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor.
Bioorganic & medicinal chemistry letters Jun, 2004 | Pubmed ID: 15149704
Sonic Hedgehog signalling in the developing and adult brain.
Journal of physiology, Paris Jan-Mar, 2002 | Pubmed ID: 11755778
Developmental expression of the cellular prion protein in elongating axons.
The European journal of neuroscience Apr, 2002 | Pubmed ID: 11982627
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.
The Journal of biological chemistry Dec, 2003 | Pubmed ID: 14506236
[Pharmacology of the extracellular calcium ion receptor].
Thérapie Sep-Oct, 2003 | Pubmed ID: 14682186
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14976203
Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients.
Cancer research May, 2004 | Pubmed ID: 15150112
Functional characterization of sonic hedgehog mutations associated with holoprosencephaly.
The Journal of biological chemistry Oct, 2004 | Pubmed ID: 15292211
N(1)-Arylsulfonyl-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes: a new class of calcilytic agents acting at the calcium-sensing receptor.
Chembiochem : a European journal of chemical biology Aug, 2004 | Pubmed ID: 15300839
In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor.
Biochemical and biophysical research communications Oct, 2004 | Pubmed ID: 15451421
[New insights into the pharmacology of the extracellular calcium sensing receptor].
Médecine sciences : M/S Nov, 2004 | Pubmed ID: 15525493
Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.
Circulation research Aug, 2005 | Pubmed ID: 16037572
Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius.
The European journal of neuroscience Jul, 2005 | Pubmed ID: 16045492
Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16135510
Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16147994
Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells.
Neuroreport Nov, 2005 | Pubmed ID: 16272887
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.
Blood Nov, 2006 | Pubmed ID: 16778137
Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle.
Journal of neurochemistry Jul, 2006 | Pubmed ID: 16805844
N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.
Journal of medicinal chemistry Aug, 2006 | Pubmed ID: 16913701
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Biochemical and biophysical research communications Oct, 2006 | Pubmed ID: 16945339
Distribution of Smoothened at hippocampal mossy fiber synapses.
Neuroreport Mar, 2007 | Pubmed ID: 17435610
Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development.
Experimental cell research Aug, 2007 | Pubmed ID: 17544395
Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.
Cell calcium Aug, 2008 | Pubmed ID: 18221783
Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb.
Stem cells (Dayton, Ohio) Sep, 2008 | Pubmed ID: 18617686
Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.
Biochimica et biophysica acta Sep, 2009 | Pubmed ID: 19463780
Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor.
Cell calcium Nov-Dec, 2009 | Pubmed ID: 19836834
Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.
PloS one , 2010 | Pubmed ID: 20052292
Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate.
Journal of cellular and molecular medicine Aug, 2009 | Pubmed ID: 20141614
Sonic Hedgehog signaling in the mammalian brain.
Journal of neurochemistry May, 2010 | Pubmed ID: 20218977
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
Molecular pharmacology Oct, 2010 | Pubmed ID: 20664000
Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists.
Bioorganic & medicinal chemistry letters Dec, 2010 | Pubmed ID: 21041081
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Molecular pharmacology Mar, 2011 | Pubmed ID: 21177415
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
Bioorganic & medicinal chemistry letters Jun, 2011 | Pubmed ID: 21592788
The hedgehog receptor patched is involved in cholesterol transport.
PloS one , 2011 | Pubmed ID: 21931618
An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.
PloS one , 2011 | Pubmed ID: 22028769
[Shh signal and its functional roles in normal and diseased brain].
Médecine sciences : M/S Nov, 2011 | Pubmed ID: 22130025
Hedgehog trafficking, cilia and brain functions.
Differentiation; research in biological diversity Feb, 2012 | Pubmed ID: 22169886
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
Journal of medicinal chemistry Feb, 2012 | Pubmed ID: 22268551
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.
Arthritis and rheumatism Aug, 2012 | Pubmed ID: 22354771
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.
Annals of the rheumatic diseases May, 2012 | Pubmed ID: 22402139
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.
The Journal of clinical investigation Sep, 2012 | Pubmed ID: 22886306
Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.
Circulation research Mar, 2013 | Pubmed ID: 23343527
Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2013 | Pubmed ID: 23365216
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.
Molecular pharmacology May, 2013 | Pubmed ID: 23448715
The choline transporter-like family SLC44: properties and roles in human diseases.
Molecular aspects of medicine Apr-Jun, 2013 | Pubmed ID: 23506897
Investigation of the proteolipid protein promoter activity during demyelination and repair.
Differentiation; research in biological diversity Apr-Jun, 2013 | Pubmed ID: 23827460
Roles of the calcium sensing receptor in the central nervous system.
Best practice & research. Clinical endocrinology & metabolism Jun, 2013 | Pubmed ID: 23856270
Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2013 | Pubmed ID: 24135022
[Structure of the Smoothened receptor].
Médecine sciences : M/S Oct, 2013 | Pubmed ID: 24148123
Targeting of Smoothened for therapeutic gain.
Trends in pharmacological sciences May, 2014 | Pubmed ID: 24703627
[Symmetric or asymmetric division: sonic Hedgehog controls the fate of neural stem cells].
Médecine sciences : M/S Jun-Jul, 2014 | Pubmed ID: 25014467
Genetic activation of Hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions.
Stem cell reports Aug, 2014 | Pubmed ID: 25254344
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2015 | Pubmed ID: 25636740
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