Martial Ruat

N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor.

Sonic Hedgehog signalling in the developing and adult brain.

Developmental expression of the cellular prion protein in elongating axons.

Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.

[Pharmacology of the extracellular calcium ion receptor].

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.

Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients.

Functional characterization of sonic hedgehog mutations associated with holoprosencephaly.

N(1)-Arylsulfonyl-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes: a new class of calcilytic agents acting at the calcium-sensing receptor.

In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor.

[New insights into the pharmacology of the extracellular calcium sensing receptor].

Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.

Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius.

Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).

Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor.

Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells.

Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.

Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle.

N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

Distribution of Smoothened at hippocampal mossy fiber synapses.

Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development.

Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.

Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb.

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor.

Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate.

Sonic Hedgehog signaling in the mammalian brain.

Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists.

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.

Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.

The hedgehog receptor patched is involved in cholesterol transport.

An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

[Shh signal and its functional roles in normal and diseased brain].

Hedgehog trafficking, cilia and brain functions.

Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.

Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.

Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination.

Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.

The choline transporter-like family SLC44: properties and roles in human diseases.

Investigation of the proteolipid protein promoter activity during demyelination and repair.

Roles of the calcium sensing receptor in the central nervous system.

Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.

[Structure of the Smoothened receptor].

Targeting of Smoothened for therapeutic gain.

[Symmetric or asymmetric division: sonic Hedgehog controls the fate of neural stem cells].

Genetic activation of Hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions.

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.