M. Sharon Stack

Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.

Ovarian cancer-associated proteinases.

Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

The mechanism of action of angiostatin: can you teach an old dog new tricks?

Analysis of matrix degradation.

Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes.

Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage.

Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells.

Loss of adhesion-regulated proteinase production is correlated with invasive activity in oral squamous cell carcinoma.

Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.

Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.

Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates.

Calcium-induced matrix metalloproteinase 9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral squamous cell carcinoma.

Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.

Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis.

Proinvasive properties of ovarian cancer ascites-derived membrane vesicles.

Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells.

Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation.

Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.

Mesenchymal transformation in epithelial ovarian tumor cells expressing epidermal growth factor receptor variant III.

Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression.

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints.

Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells.

Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells.

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.

Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.

Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.

Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity.

Synthesis and anticancer activities of 6-amino amonafide derivatives.

Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion.

Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma.

Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression.

Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner.

Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells.

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.

Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.

Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.

EGF-receptor regulation of matrix metalloproteinases in epithelial ovarian carcinoma.

Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices.

Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen.

Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.

Activated epidermal growth factor receptor in ovarian cancer.

Microenvironmental regulation of ovarian cancer metastasis.

Targeting the EGF receptor for ovarian cancer therapy.

Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression.

Masticatory loading, function, and plasticity: a microanatomical analysis of mammalian circumorbital soft-tissue structures.

Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma.

Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.

Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts.

Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.

Integrin regulation of beta-catenin signaling in ovarian carcinoma.

Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.

Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.

Using "Mighty Mouse" to understand masticatory plasticity: myostatin-deficient mice and musculoskeletal function.

Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.

The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration.

Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma.

Lysophosphatidic Acid disrupts junctional integrity and epithelial cohesion in ovarian cancer cells.

Fluorescence In Situ Hybridization for MicroRNA Detection in Archived Oral Cancer Tissues.

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.

Detecting microRNA in human cancer tissues with fluorescence in situ hybridization.

Inhibitors of NF-kappaB reverse cellular invasion and target gene upregulation in an experimental model of aggressive oral squamous cell carcinoma.

An ion-exchange nanomembrane sensor for detection of nucleic acids using a surface charge inversion phenomenon.

Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.

Correlation of X-ray computed tomography with quantitative nuclear magnetic resonance methods for pre-clinical measurement of adipose and lean tissues in living mice.

Identification of a human papillomavirus-associated oncogenic miRNA panel in human oropharyngeal squamous cell carcinoma validated by bioinformatics analysis of the Cancer Genome Atlas.

Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma.

Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma.

Integrated, DC voltage-driven nucleic acid diagnostic platform for real sample analysis: Detection of oral cancer.

Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages.

Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma.

Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells.

Aggressive breast cancer in western Kenya has early onset, high proliferation, and immune cell infiltration.