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Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.
Biophysical journal Jul, 2002 | Pubmed ID: 12080120
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension.
Nature structural biology Sep, 2002 | Pubmed ID: 12172538
On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.
The Journal of general physiology Mar, 2003 | Pubmed ID: 12601086
Mechanosensitive channels: multiplicity of families and gating paradigms.
Science's STKE : signal transduction knowledge environment Feb, 2004 | Pubmed ID: 14872099
Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responses.
Biophysical journal May, 2004 | Pubmed ID: 15111402
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.
Biophysical journal May, 2004 | Pubmed ID: 15111405
Mechanosensitive channels: what can we learn from 'simple' model systems?
Trends in neurosciences Jun, 2004 | Pubmed ID: 15165739
The "dashpot" mechanism of stretch-dependent gating in MscS.
The Journal of general physiology Feb, 2005 | Pubmed ID: 15657299
Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL.
The Journal of general physiology Feb, 2005 | Pubmed ID: 15684093
Explicit channel conductance: can it be computed?
Biophysical journal Jun, 2005 | Pubmed ID: 15764668
Capping transmembrane helices of MscL with aromatic residues changes channel response to membrane stretch.
Biochemistry Sep, 2005 | Pubmed ID: 16156671
2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS.
Biophysical journal Apr, 2007 | Pubmed ID: 17277184
Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance.
Biophysical journal Feb, 2008 | Pubmed ID: 17981908
Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS.
Nature structural & molecular biology Dec, 2007 | Pubmed ID: 18037888
Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance.
The Journal of general physiology Jul, 2008 | Pubmed ID: 18591417
The membrane lateral pressure-perturbing capacity of parabens and their effects on the mechanosensitive channel directly correlate with hydrophobicity.
Biochemistry Oct, 2008 | Pubmed ID: 18795793
State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19383606
The tension-transmitting 'clutch' in the mechanosensitive channel MscS.
Nature structural & molecular biology Apr, 2010 | Pubmed ID: 20208543
Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids.
Biophysical journal Mar, 2010 | Pubmed ID: 20303859
Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics.
The Journal of general physiology Jun, 2010 | Pubmed ID: 20513760
Mechanosensitive channels in microbes.
Annual review of microbiology , 2010 | Pubmed ID: 20825352
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts.
Biophysical journal Nov, 2010 | Pubmed ID: 21044584
Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.
Channels (Austin, Tex.) Jan-Feb, 2011 | Pubmed ID: 21057213
Structural models of TREK channels and their gating mechanism.
Channels (Austin, Tex.) Jan-Feb, 2011 | Pubmed ID: 21084863
Adaptive MscS gating in the osmotic permeability response in E. coli: the question of time.
Biochemistry May, 2011 | Pubmed ID: 21456519
The pathway and spatial scale for MscS inactivation.
The Journal of general physiology Jul, 2011 | Pubmed ID: 21670207
Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules.
Biochemistry Aug, 2011 | Pubmed ID: 21736305
Molecular force transduction by ion channels: diversity and unifying principles.
Journal of cell science Jul, 2012 | Pubmed ID: 22797911
The mechanoelectrical response of the cytoplasmic membrane of Vibrio cholerae.
The Journal of general physiology Jul, 2013 | Pubmed ID: 23797422
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.
Blood Jun, 2014 | Pubmed ID: 24659632
The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding.
The Journal of general physiology May, 2014 | Pubmed ID: 24778428
Properties of diphytanoyl phospholipids at the air-water interface.
Langmuir : the ACS journal of surfaces and colloids Jan, 2015 | Pubmed ID: 25474305
Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.
Journal of molecular biology Aug, 2015 | Pubmed ID: 26142822
Membrane Affinity of Platensimycin and Its Dialkylamine Analogs.
International journal of molecular sciences , 2015 | Pubmed ID: 26247942
Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations.
Biochimica et biophysica acta Nov, 2015 | Pubmed ID: 26342676
Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers.
Scientific reports , 2015 | Pubmed ID: 26348441
Joseph S. Najem1,
Myles D. Dunlap2,
Anthony Yasmann3,
Eric C. Freeman4,
John W. Grant5,
Sergei Sukharev3,
Donald J. Leo4
1Department of Mechanical Engineering, Virginia Polytechnic Institute and State University,
2School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University,
3Department of Biology, University of Maryland,
4College of Engineering, University of Georgia,
5Department of Engineering Sciences and Mechanics, Virginia Polytechnic Institute and State University
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