Oliver Smithies

Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy.

Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.

Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice.

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene.

Impaired T cell function in RANTES-deficient mice.

Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration.

Multiple roles of adrenomedullin revealed by animal models.

Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice.

A genetically clamped renin transgene for the induction of hypertension.

Targeted disruption of hsp70.1 sensitizes to osmotic stress.

Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function.

Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system.

Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion.

Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm.

Physiological impact of increased expression of the AT1 angiotensin receptor.

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.

Human genetics, animal models and computer simulations for studying hypertension.

Altering the expression in mice of genes by modifying their 3' regions.

Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.

E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.

Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.

Three-dimensional diffusion tensor microscopy of fixed mouse hearts.

Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences.

Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type.

Lifelong genetic minipumps.

Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro.

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.

Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene.

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

Many little things: one geneticist's view of complex diseases.

An interview with... Oliver Smithies [interviewed by Magdalena Skipper].

Kidney function in mice lacking aldosterone.

An improved technique for tail-cuff blood pressure measurements with dark-tailed mice.

Isolating gene-corrected stem cells without drug selection.

Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene.

Amino acids as modulators of endothelium-derived nitric oxide.

Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.

A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation.

Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo.

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis.

Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.

Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.

Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age.

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice.

Turning pages (Nobel lecture).

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.

Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera.

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice.

The kallikrein-kinin system in health and in diseases of the kidney.

Gender-dependent survival of allogeneic trophoblast stem cells in liver.

Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.

Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.

Mouse models of diabetic nephropathy.

Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.

Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure.

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia.

Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.

Science brick by brick.

Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells.

A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy.

Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.

Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.

β-MyHC and cardiac hypertrophy: size does matter.

The kallikrein-kinin system and oxidative stress.

Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility.

eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.

The kallikrein-kinin system in diabetic nephropathy.

How it all began: a personal history of gel electrophoresis.

Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression.

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.

Colour blindness: still too many red-green figures.

Stable oligomeric clusters of gold nanoparticles: preparation, size distribution, derivatization, and physical and biological properties.

Transforming growth factor beta1 and aldosterone.

A conversation with Oliver Smithies.

The role of transforming growth factor β1 in the regulation of blood pressure.

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.

Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.

The whole of a scientific career: an interview with Oliver Smithies.

A conversation with Oliver Smithies.

Transforming growth factor β1 and diabetic nephropathy.