Department of Pathology and Laboratory Medicine
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Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology Jan, 2002 | Pubmed ID: 11748047
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
Science (New York, N.Y.) Jan, 2002 | Pubmed ID: 11799247
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice.
The Journal of clinical investigation Feb, 2002 | Pubmed ID: 11854327
Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene.
Journal of the American Society of Nephrology : JASN Mar, 2002 | Pubmed ID: 11856763
Impaired T cell function in RANTES-deficient mice.
Clinical immunology (Orlando, Fla.) Mar, 2002 | Pubmed ID: 11890717
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2002 | Pubmed ID: 11904385
Multiple roles of adrenomedullin revealed by animal models.
Microscopy research and technique Apr, 2002 | Pubmed ID: 11921356
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice.
Hormones and behavior May, 2002 | Pubmed ID: 11971662
A genetically clamped renin transgene for the induction of hypertension.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2002 | Pubmed ID: 12034874
Targeted disruption of hsp70.1 sensitizes to osmotic stress.
EMBO reports Sep, 2002 | Pubmed ID: 12189176
Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12655073
Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system.
Endocrinology Jun, 2003 | Pubmed ID: 12746272
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion.
American journal of physiology. Renal physiology Oct, 2003 | Pubmed ID: 12824076
Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm.
Surgery Aug, 2003 | Pubmed ID: 12947317
Physiological impact of increased expression of the AT1 angiotensin receptor.
Hypertension Oct, 2003 | Pubmed ID: 12963678
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 14978280
Human genetics, animal models and computer simulations for studying hypertension.
Trends in genetics : TIG Mar, 2004 | Pubmed ID: 15036807
Altering the expression in mice of genes by modifying their 3' regions.
Developmental cell Apr, 2004 | Pubmed ID: 15068798
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.
Developmental cell May, 2004 | Pubmed ID: 15130496
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2004 | Pubmed ID: 15240726
A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
Physiological genomics Aug, 2004 | Pubmed ID: 15306694
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2004 | Pubmed ID: 15326315
Three-dimensional diffusion tensor microscopy of fixed mouse hearts.
Magnetic resonance in medicine Sep, 2004 | Pubmed ID: 15334561
Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences.
Genomics Sep, 2004 | Pubmed ID: 15498455
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type.
Journal of the American Society of Nephrology : JASN Jan, 2005 | Pubmed ID: 15563565
Lifelong genetic minipumps.
Physiological genomics Jan, 2005 | Pubmed ID: 15585607
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15699326
Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.
Endocrinology Jun, 2005 | Pubmed ID: 15731365
Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene.
Cardiovascular research Apr, 2005 | Pubmed ID: 15769452
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.
The Journal of clinical investigation Apr, 2005 | Pubmed ID: 15841186
Many little things: one geneticist's view of complex diseases.
Nature reviews. Genetics May, 2005 | Pubmed ID: 15861211
An interview with... Oliver Smithies [interviewed by Magdalena Skipper].
Nature reviews. Genetics May, 2005 | Pubmed ID: 15880879
Kidney function in mice lacking aldosterone.
American journal of physiology. Renal physiology Jan, 2006 | Pubmed ID: 16118390
An improved technique for tail-cuff blood pressure measurements with dark-tailed mice.
Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science Sep, 2005 | Pubmed ID: 16138782
Isolating gene-corrected stem cells without drug selection.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2005 | Pubmed ID: 16258059
Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene.
Molecular and cellular biology Apr, 2006 | Pubmed ID: 16537897
Amino acids as modulators of endothelium-derived nitric oxide.
American journal of physiology. Renal physiology Aug, 2006 | Pubmed ID: 16571593
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.
The Journal of clinical investigation May, 2006 | Pubmed ID: 16604193
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
The Journal of clinical investigation Jun, 2006 | Pubmed ID: 16741575
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2006 | Pubmed ID: 16777957
Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.
The Journal of biological chemistry Aug, 2006 | Pubmed ID: 16782708
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.
The Journal of clinical investigation Oct, 2006 | Pubmed ID: 16981008
Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17068123
Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.
Hypertension Dec, 2006 | Pubmed ID: 17075030
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17090678
Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis.
Journal of molecular endocrinology Feb, 2007 | Pubmed ID: 17293444
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2007 | Pubmed ID: 17360661
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.
The Journal of clinical investigation May, 2007 | Pubmed ID: 17431507
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17452647
Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age.
The Journal of biological chemistry Jun, 2007 | Pubmed ID: 17470425
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.
Molecular and cellular biology Aug, 2007 | Pubmed ID: 17526730
Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.
Hypertension Jan, 2008 | Pubmed ID: 18039983
Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice.
Experimental physiology May, 2008 | Pubmed ID: 18192335
Turning pages (Nobel lecture).
Chembiochem : a European journal of chemical biology Jun, 2008 | Pubmed ID: 18543237
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18755891
Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera.
Journal of clinical hypertension (Greenwich, Conn.) Aug, 2008 | Pubmed ID: 18772647
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2009 | Pubmed ID: 19164558
The kallikrein-kinin system in health and in diseases of the kidney.
Kidney international May, 2009 | Pubmed ID: 19190676
Gender-dependent survival of allogeneic trophoblast stem cells in liver.
Cell transplantation , 2009 | Pubmed ID: 19523327
Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.
European journal of heart failure Jul, 2009 | Pubmed ID: 19553396
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.
PloS one , 2009 | Pubmed ID: 19696925
Mouse models of diabetic nephropathy.
Journal of the American Society of Nephrology : JASN Dec, 2009 | Pubmed ID: 19729434
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.
Biochimica et biophysica acta Dec, 2009 | Pubmed ID: 19782130
Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19884495
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.
Journal of immunology (Baltimore, Md. : 1950) May, 2010 | Pubmed ID: 20410496
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20479236
Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.
Endocrinology Aug, 2010 | Pubmed ID: 20501666
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2010 | Pubmed ID: 20667972
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2010 | Pubmed ID: 20923879
Science brick by brick.
Nature Oct, 2010 | Pubmed ID: 20944621
Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells.
Experimental hematology Mar, 2011 | Pubmed ID: 21184801
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21245338
Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.
Gene expression , 2010 | Pubmed ID: 21526716
Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.
Proceedings of the National Academy of Sciences of the United States of America May, 2011 | Pubmed ID: 21555558
β-MyHC and cardiac hypertrophy: size does matter.
Circulation research Sep, 2011 | Pubmed ID: 21885833
The kallikrein-kinin system and oxidative stress.
Current opinion in nephrology and hypertension Jan, 2012 | Pubmed ID: 22048723
Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22222526
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.
Journal of the American Society of Nephrology : JASN Apr, 2012 | Pubmed ID: 22282588
The kallikrein-kinin system in diabetic nephropathy.
Kidney international Apr, 2012 | Pubmed ID: 22318421
How it all began: a personal history of gel electrophoresis.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22585472
Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression.
Gene expression , 2012 | Pubmed ID: 22783727
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.
American journal of physiology. Renal physiology Dec, 2012 | Pubmed ID: 23019230
Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23503843
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.
Nature communications , 2013 | Pubmed ID: 24335996
Colour blindness: still too many red-green figures.
Nature Jun, 2014 | Pubmed ID: 24943948
Stable oligomeric clusters of gold nanoparticles: preparation, size distribution, derivatization, and physical and biological properties.
Langmuir : the ACS journal of surfaces and colloids Nov, 2014 | Pubmed ID: 25317930
Transforming growth factor beta1 and aldosterone.
Current opinion in nephrology and hypertension Mar, 2015 | Pubmed ID: 25587902
A conversation with Oliver Smithies.
Annual review of physiology , 2015 | Pubmed ID: 25668016
The role of transforming growth factor β1 in the regulation of blood pressure.
Current hypertension reviews , 2014 | Pubmed ID: 25801626
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2015 | Pubmed ID: 25848038
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.
Proceedings of the National Academy of Sciences of the United States of America May, 2015 | Pubmed ID: 25902541
The whole of a scientific career: an interview with Oliver Smithies.
PLoS genetics May, 2015 | Pubmed ID: 26020970
A conversation with Oliver Smithies.
The Journal of clinical investigation Nov, 2015 | Pubmed ID: 26524588
Transforming growth factor β1 and diabetic nephropathy.
American journal of physiology. Renal physiology Dec, 2015 | Pubmed ID: 26719364