David Ornitz

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.

Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14.

Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.

Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains.

Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.

Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation.

Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.

A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3.

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth.

Expression and function of FGF10 in mammalian inner ear development.

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.

Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.

Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.

A twist code determines the onset of osteoblast differentiation.

Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.

Conserved roles for Slit and Robo proteins in midline commissural axon guidance.

Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.

Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice.

Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions.

Evolution of the Fgf and Fgfr gene families.

Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.

Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.

Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.

FGF signaling in the developing endochondral skeleton.

Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.

Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels.

Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development.

Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.

Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development.

FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti.

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation.

FGF signalling generates ventral telencephalic cells independently of SHH.

A model for the pharmacological treatment of crouzon syndrome.

Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.

Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.

Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14.

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.

Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14.

Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization.

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.

Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.

Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.

Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.

The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.

Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center.

Functional evolutionary history of the mouse Fgf gene family.

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.

Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.

Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.

Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue.

Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.

An FGF-WNT gene regulatory network controls lung mesenchyme development.

Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.

FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.

Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.

FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.

Fibroblast growth factor expression during skeletal fracture healing in mice.

Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.

Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.

Healing of non-displaced fractures produced by fatigue loading of the mouse ulna.

Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1.

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.

Regulation of cellular calcium in vestibular supporting cells by otopetrin 1.

In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.

FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice.

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.

Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells.

Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses.

Histomorphological study of palatal shelf elevation during murine secondary palate formation.

Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development.

FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.

Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.

Signaling networks regulating development of the lower respiratory tract.

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.

Genomic landscape of non-small cell lung cancer in smokers and never-smokers.

FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin.

Development of the endochondral skeleton.

Delineating a conserved genetic cassette promoting outgrowth of body appendages.

Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.

Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.

FGF14 localization and organization of the axon initial segment.

Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.

Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice.

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.

FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.

Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.

Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo.

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma.

Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury.

Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.

The Fibroblast Growth Factor signaling pathway.

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.

Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.

Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.

Fibroblast growth factor signaling in skeletal development and disease.

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.

Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury.

A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development.

Proteomic analysis of native cerebellar iFGF14 complexes.

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.

Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.