Thulasi Warrier

Old fold in a new X-ray diffraction dataset? Low-resolution molecular replacement using representative structural templates can provide phase information.

Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.

X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).

Identification of small-molecule scaffolds for p450 inhibitors.

Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis.

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.

Benzimidazole-based compounds kill Mycobacterium tuberculosis.

Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis.

A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis.

Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis.