Sivaraj Sivaramakrishnan

Micromechanical properties of keratin intermediate filament networks.

Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI.

Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif.

Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.

Coupled myosin VI motors facilitate unidirectional movement on an F-actin network.

Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.

Insights into human beta-cardiac myosin function from single molecule and single cell studies.

Single-molecule dual-beam optical trap analysis of protein structure and function.

Helicity of short E-R/K peptides.

Principles of unconventional myosin function and targeting.

Systematic control of protein interaction using a modular ER/K α-helix linker.

Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.

Visualizing and manipulating focal adhesion kinase regulation in live cells.

Highly sensitive fluorescent protein FRET detection using optofluidic lasers.

Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.

Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.

Analyses of conformational states of the transporter associated with antigen processing (TAP) protein in a native cellular membrane environment.

Myosin lever arm directs collective motion on cellular actin network.

Conserved modular domains team up to latch-open active protein kinase Cα.

Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.

Harnessing the unique structural properties of isolated α-helices.

Optofluidic lasers with a single molecular layer of gain.

A method for multiprotein assembly in cells reveals independent action of kinesins in complex.

Tuning myosin-driven sorting on cellular actin networks.

The C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ Activity.

Cellular chirality arising from the self-organization of the actin cytoskeleton.

Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds.

Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins.

Correlation between Activity and Domain Complementation in Adenylyl Cyclase Demonstrated with a Novel Fluorescence Resonance Energy Transfer Sensor.

Structural Elements in the Gαs and Gαq C Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling.

Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency.

Engineering Circular Gliding of Actin Filaments Along Myosin-Patterned DNA Nanotube Rings to Study Long-Term Actin-Myosin Behaviors.