Zilkha Neurogenetic Institute
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CD40 is expressed and functional on neuronal cells.
The EMBO journal Feb, 2002 | Pubmed ID: 11847112
p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.
Journal of neuroscience research Aug, 2002 | Pubmed ID: 12125077
CD40-CD40L interaction in Alzheimer's disease.
Current opinion in pharmacology Aug, 2002 | Pubmed ID: 12127879
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Nature neuroscience Dec, 2002 | Pubmed ID: 12402041
Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42).
Journal of neuroimmunology Nov, 2002 | Pubmed ID: 12417433
CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease.
Journal of neuroimmunology Nov, 2002 | Pubmed ID: 12417447
Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.
Journal of neuropathology and experimental neurology Mar, 2003 | Pubmed ID: 12638732
Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production.
Glia May, 2004 | Pubmed ID: 15095367
CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice.
Neuroscience letters May, 2004 | Pubmed ID: 15147773
Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2004 | Pubmed ID: 15181372
Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.
Brain research Jul, 2004 | Pubmed ID: 15223380
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.
Nature medicine Dec, 2004 | Pubmed ID: 15558055
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.
European journal of immunology Mar, 2005 | Pubmed ID: 15688347
Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2005 | Pubmed ID: 15689951
Interchromosomal associations between alternatively expressed loci.
Nature Jun, 2005 | Pubmed ID: 15880101
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2005 | Pubmed ID: 15944381
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2005 | Pubmed ID: 16177050
T-cells in Alzheimer's disease.
Neuromolecular medicine , 2005 | Pubmed ID: 16247185
The microglial "activation" continuum: from innate to adaptive responses.
Journal of neuroinflammation Oct, 2005 | Pubmed ID: 16259628
Microglia recognize double-stranded RNA via TLR3.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2006 | Pubmed ID: 16517751
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16624814
Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.
The Journal of pharmacology and experimental therapeutics Aug, 2006 | Pubmed ID: 16709678
HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways.
The Journal of surgical research Nov, 2006 | Pubmed ID: 16979664
Antiviral peptides targeting the west nile virus envelope protein.
Journal of virology Feb, 2007 | Pubmed ID: 17151121
Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2007 | Pubmed ID: 17264212
NSAIDs for the chemoprevention of Alzheimer's disease.
Sub-cellular biochemistry , 2007 | Pubmed ID: 17612054
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.
Hepatology (Baltimore, Md.) Nov, 2007 | Pubmed ID: 17705260
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.
The Journal of clinical investigation Oct, 2007 | Pubmed ID: 17909632
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.
Immunity Nov, 2007 | Pubmed ID: 17997333
Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host.
The Journal of infectious diseases Nov, 2007 | Pubmed ID: 18008236
West Nile virus envelope protein inhibits dsRNA-induced innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2007 | Pubmed ID: 18056386
Icam-1 participates in the entry of west nile virus into the central nervous system.
Journal of virology Apr, 2008 | Pubmed ID: 18256150
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18287022
Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice.
Stem cells and development Jun, 2008 | Pubmed ID: 18366296
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18367668
Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production.
Journal of cellular and molecular medicine Mar, 2009 | Pubmed ID: 18410522
Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia.
Stroke Jul, 2008 | Pubmed ID: 18451356
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Nature medicine Jun, 2008 | Pubmed ID: 18516051
Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2008 | Pubmed ID: 18641347
TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2008 | Pubmed ID: 18669656
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18728187
Inflammaging as a prodrome to Alzheimer's disease.
Journal of neuroinflammation Nov, 2008 | Pubmed ID: 19014446
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.
Immunity Feb, 2009 | Pubmed ID: 19200759
Approaches to determine expression of inflammatory cytokines.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19347295
Alternative Abeta immunotherapy approaches for Alzheimer's disease.
CNS & neurological disorders drug targets Apr, 2009 | Pubmed ID: 19355932
A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages.
Virology journal May, 2009 | Pubmed ID: 19439086
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Nature immunology Jun, 2009 | Pubmed ID: 19448631
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Dec, 2009 | Pubmed ID: 19669892
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.
Glia Feb, 2010 | Pubmed ID: 19705461
IL-10 signaling blockade controls murine West Nile virus infection.
PLoS pathogens Oct, 2009 | Pubmed ID: 19816558
Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.
Journal of cellular and molecular medicine Feb, 2011 | Pubmed ID: 19900216
Can peripheral leukocytes be used as Alzheimer's disease biomarkers?
Expert review of neurotherapeutics Nov, 2009 | Pubmed ID: 19903022
Inflammation, immunity, and Alzheimer's disease.
CNS & neurological disorders drug targets Apr, 2010 | Pubmed ID: 20205648
Alzheimer's Disease Beyond Abeta.
Expert review of neurotherapeutics May, 2010 | Pubmed ID: 20429127
Macrophages in Alzheimer's disease: the blood-borne identity.
Journal of neural transmission (Vienna, Austria : 1996) Aug, 2010 | Pubmed ID: 20517700
Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease.
Cardiovascular psychiatry and neurology , 2010 | Pubmed ID: 20862385
Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.
Investigative ophthalmology & visual science Apr, 2011 | Pubmed ID: 21220560
CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2011 | Pubmed ID: 21273420
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Journal of virology May, 2011 | Pubmed ID: 21307196
Control of TH17 cells occurs in the small intestine.
Nature Jul, 2011 | Pubmed ID: 21765430
Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.
Journal of virology Nov, 2011 | Pubmed ID: 21880769
Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2011 | Pubmed ID: 21918188
Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22219198
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Immunity Mar, 2012 | Pubmed ID: 22342844
Basic biology and mechanisms of neural ciliogenesis and the B9 family.
Molecular neurobiology Jun, 2012 | Pubmed ID: 22644387
Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.
Neural development , 2012 | Pubmed ID: 22776033
Microglia in Alzheimer's Disease: It's All About Context.
International journal of Alzheimer's disease , 2012 | Pubmed ID: 22779026
IL-22 signaling contributes to West Nile encephalitis pathogenesis.
PloS one , 2012 | Pubmed ID: 22952908
Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice.
PloS one , 2013 | Pubmed ID: 23409038
Increasing hematopoietic stem cell yield to develop mice with human immune systems.
BioMed research international , 2013 | Pubmed ID: 23509770
Innate immunity in Alzheimer's disease: a complex affair.
CNS & neurological disorders drug targets Aug, 2013 | Pubmed ID: 23574177
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2013 | Pubmed ID: 23575824
Brain injury, neuroinflammation and Alzheimer's disease.
Frontiers in aging neuroscience , 2013 | Pubmed ID: 23874297
CD8α dendritic cells drive establishment of HSV-1 latency.
PloS one , 2014 | Pubmed ID: 24695322
T-cell TGF-β signaling abrogation restricts medulloblastoma progression.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2014 | Pubmed ID: 25082897
Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25157105
MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice.
The American journal of pathology Nov, 2014 | Pubmed ID: 25174876
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
Brain research Aug, 2015 | Pubmed ID: 25218556
Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.
Neuron Feb, 2015 | Pubmed ID: 25619654
Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2015 | Pubmed ID: 25770217
Neuroinflammation in Alzheimer's disease.
The Lancet. Neurology Apr, 2015 | Pubmed ID: 25792098
Characterization of cancer stem cells and primary cilia in medulloblastoma.
CNS & neurological disorders drug targets , 2015 | Pubmed ID: 25921740
Innate Immunity Fights Alzheimer's Disease.
Trends in neurosciences Nov, 2015 | Pubmed ID: 26549882
Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection.
PLoS pathogens , 2015 | Pubmed ID: 26618545
Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats.
PloS one , 2015 | Pubmed ID: 26683657
CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1.
Journal of virology May, 2016 | Pubmed ID: 26962220
Targeting innate immunity for neurodegenerative disorders of the central nervous system.
Journal of neurochemistry Sep, 2016 | Pubmed ID: 27248001
Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice.
Journal of virology Oct, 2016 | Pubmed ID: 27512072
Amyloid Cascade into Clarity.
Immunity Oct, 2016 | Pubmed ID: 27760336
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.
Journal of virology Jan, 2017 | Pubmed ID: 27795421
TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2016 | Pubmed ID: 27798161
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