Jorge Z. Torres

Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p.

Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities.

The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.

The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.

High-throughput generation of tagged stable cell lines for proteomic analysis.

A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles.

The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

STARD9/Kif16a is a novel mitotic kinesin and antimitotic target.

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Dynamic and multi-pharmacophore modeling for designing polo-box domain inhibitors.

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

A unique insertion in STARD9's motor domain regulates its stability.

Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens.

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.

Structures of potent anticancer compounds bound to tubulin.

The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.

Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.

Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB.

3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping.

Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division.