Yossef Av-Gay

Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast.

Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.

Identification and characterization of a diamide sensitive mutant of Mycobacterium smegmatis.

Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.

Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics.

Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.

The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence.

Development of a liposome formulation of ethambutol.

The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo.

Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein.

Screening of Compounds Toxicity against Human Monocytic cell line-THP-1 by Flow Cytometry.

Thiol specific oxidative stress response in Mycobacteria.

Mycobacterial manipulation of the host cell.

Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.

Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S.

In vitro properties of antimicrobial bromotyrosine alkaloids.

Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme.

Mycothiol-dependent mycobacterial response to oxidative stress.

Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD.

Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection.

Mycothiol-dependent proteins in actinomycetes.

Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.

Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.

Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation.

Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages.

Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF.

Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis.

Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B.

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure.

The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.

Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA.

Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system.

Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis.

Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli.

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.

Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles.

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.

Antimycobacterial activity of UDP-galactopyranose mutase inhibitors.

MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis.

Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin.

Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis.

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum.

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.

Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.

Comparative efficacy of commercially available and emerging antimicrobial urinary catheters against bacteriuria caused by E. coli in vitro.

Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta.

The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance.

Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.

A phase I clinical study of inhaled nitric oxide in healthy adults.

Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Laennecia confusa.

Mycobacterium tuberculosis modulators of the macrophage's cellular events.

Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo.

Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development.

Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.

Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles.

Gaseous nitric oxide reduces influenza infectivity in vitro.

Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.

Microbial protein-tyrosine kinases.

Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α.

Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.

Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis.

Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.

Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases.

Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages.

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.

Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms.

Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics.

Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and Persistence.