Department of Chemistry,
Center of Diagnostics and Therapeutics (CDT),
Department of Chemistry, Center of Diagnostics and Therapeutics (CDT)
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Temperature-induced formation of a non-native intermediate state of the all beta-sheet protein CD2.
Cell biochemistry and biophysics , 2002 | Pubmed ID: 11939369
Structural analysis, identification, and design of calcium-binding sites in proteins.
Proteins May, 2002 | Pubmed ID: 11948788
Isolated EF-loop III of calmodulin in a scaffold protein remains unpaired in solution using pulsed-field-gradient NMR spectroscopy.
Biochimica et biophysica acta Jul, 2002 | Pubmed ID: 12147347
Metal-binding studies for a de novo designed calcium-binding protein.
Protein engineering Jul, 2002 | Pubmed ID: 12200539
Rational design of a calcium-binding protein.
Journal of the American Chemical Society May, 2003 | Pubmed ID: 12785848
A grafting approach to obtain site-specific metal-binding properties of EF-hand proteins.
Protein engineering Jun, 2003 | Pubmed ID: 12874376
Obtaining site-specific calcium-binding affinities of calmodulin.
Protein and peptide letters Aug, 2003 | Pubmed ID: 14529487
Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
Journal of the American Chemical Society Feb, 2005 | Pubmed ID: 15713084
Probing site-specific calmodulin calcium and lanthanide affinity by grafting.
Journal of the American Chemical Society Mar, 2005 | Pubmed ID: 15771508
Calcium and lanthanide affinity of the EF-loops from the C-terminal domain of calmodulin.
Journal of inorganic biochemistry Jun, 2005 | Pubmed ID: 15917089
Expression and optical properties of green fluorescent protein expressed in different cellular environments.
Journal of biotechnology Oct, 2005 | Pubmed ID: 15935502
The effects of Ca2+ binding on the dynamic properties of a designed Ca2+-binding protein.
Biochemistry Jun, 2005 | Pubmed ID: 15938616
ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome.
Molecular and cellular biology Sep, 2005 | Pubmed ID: 16107697
Amyloid fibril formation by a domain of rat cell adhesion molecule.
Cell biochemistry and biophysics , 2006 | Pubmed ID: 16456226
Predicting calcium-binding sites in proteins - a graph theory and geometry approach.
Proteins Jul, 2006 | Pubmed ID: 16617426
Using protein design to dissect the effect of charged residues on metal binding and protein stability.
Biochemistry May, 2006 | Pubmed ID: 16669627
Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins.
Proteins Nov, 2006 | Pubmed ID: 16981205
Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47.
Journal of molecular biology Jan, 2007 | Pubmed ID: 17070842
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.
The Journal of biological chemistry Jun, 2007 | Pubmed ID: 17478419
Identification of the calmodulin binding domain of connexin 43.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17901047
Developing sensors for real-time measurement of high Ca2+ concentrations.
Biochemistry Oct, 2007 | Pubmed ID: 17924653
Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.
Protein science : a publication of the Protein Society Mar, 2008 | Pubmed ID: 18287277
Rational design of protein-based MRI contrast agents.
Journal of the American Chemical Society Jul, 2008 | Pubmed ID: 18576649
Statistical analysis of structural characteristics of protein Ca2+-binding sites.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Sep, 2008 | Pubmed ID: 18594878
Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicity.
Journal of inorganic biochemistry Oct, 2008 | Pubmed ID: 18684507
Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites.
The FEBS journal Oct, 2008 | Pubmed ID: 18785925
A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication.
The Biochemical journal Jan, 2009 | Pubmed ID: 18795894
Design, synthesis, and characterization of a calcium-sensitive near infrared dye.
Talanta Apr, 2002 | Pubmed ID: 18968590
Towards predicting Ca2+-binding sites with different coordination numbers in proteins with atomic resolution.
Proteins Jun, 2009 | Pubmed ID: 19003991
Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response.
Biochemistry Jan, 2009 | Pubmed ID: 19102677
Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells.
Biochemistry Apr, 2009 | Pubmed ID: 19271729
Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.
Biophysical journal Apr, 2009 | Pubmed ID: 19348766
Facilitating chromophore formation of engineered Ca(2+) binding green fluorescent proteins.
Archives of biochemistry and biophysics Jun, 2009 | Pubmed ID: 19358822
Fluorescence complementation via EF-hand interactions.
Journal of biotechnology Jul, 2009 | Pubmed ID: 19500621
Viral calciomics: interplays between Ca2+ and virus.
Cell calcium Jul, 2009 | Pubmed ID: 19535138
Designing caspase-3 sensors for imaging of apoptosis in living cells.
Chemistry (Weinheim an der Bergstrasse, Germany) Sep, 2009 | Pubmed ID: 19655355
A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+.
The FEBS journal Oct, 2009 | Pubmed ID: 19694801
Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins.
PMC biophysics Dec, 2009 | Pubmed ID: 20025729
Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.
The Journal of biological chemistry Mar, 2010 | Pubmed ID: 20086014
Analysis and prediction of calcium-binding pockets from apo-protein structures exhibiting calcium-induced localized conformational changes.
Protein science : a publication of the Protein Society Jun, 2010 | Pubmed ID: 20512971
Protein-based MRI contrast agents for molecular imaging of prostate cancer.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Jun, 2011 | Pubmed ID: 20574851
Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20705606
Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to Production.
Current bioinformatics Mar, 2010 | Pubmed ID: 20802832
Site-specific modification of calmodulin Ca²(+) affinity tunes the skeletal muscle ryanodine receptor activation profile.
The Biochemical journal Nov, 2010 | Pubmed ID: 20815817
Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20826781
Molecular interaction and functional regulation of connexin50 gap junctions by calmodulin.
The Biochemical journal May, 2011 | Pubmed ID: 21320072
HER2 targeted molecular MR imaging using a de novo designed protein contrast agent.
PloS one Mar, 2011 | Pubmed ID: 21455310
Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21914846
PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilities.
Journal of inorganic biochemistry Feb, 2012 | Pubmed ID: 22178673
Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice.
Pflugers Archiv : European journal of physiology Apr, 2012 | Pubmed ID: 22249494
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.
Molecular cell Mar, 2012 | Pubmed ID: 22306293
Role of calcium in metalloenzymes: effects of calcium removal on the axial ligation geometry and magnetic properties of the catalytic diheme center in MauG.
Biochemistry Feb, 2012 | Pubmed ID: 22320333
Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.
American journal of physiology. Cell physiology May, 2012 | Pubmed ID: 22422398
Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.
Human molecular genetics Jun, 2012 | Pubmed ID: 22422767
Predicting Ca2+ -binding sites using refined carbon clusters.
Proteins Jul, 2012 | Pubmed ID: 22821762
Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems.
Metallomics : integrated biometal science Jan, 2013 | Pubmed ID: 23235533
Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23296603
Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis.
Nature communications , 2013 | Pubmed ID: 23322042
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Mar-Apr, 2013 | Pubmed ID: 23335551
Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23576436
Metal toxicity and opportunistic binding of Pb(2+) in proteins.
Journal of inorganic biochemistry Aug, 2013 | Pubmed ID: 23692958
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.
The Journal of biological chemistry Jan, 2014 | Pubmed ID: 24280223
Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.
Acta crystallographica. Section D, Biological crystallography Dec, 2013 | Pubmed ID: 24311573
Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Feb, 2014 | Pubmed ID: 24366655
Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.
The Journal of biological chemistry Feb, 2014 | Pubmed ID: 24394414
Gap junction regulation by calmodulin.
FEBS letters Apr, 2014 | Pubmed ID: 24440348
Design of ProCAs (protein-based Gd(3+) MRI contrast agents) with high dose efficiency and capability for molecular imaging of cancer biomarkers.
Medicinal research reviews Sep, 2014 | Pubmed ID: 24615853
Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.
The Biochemical journal Jun, 2014 | Pubmed ID: 24635445
Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.
Diabetes Apr, 2014 | Pubmed ID: 24651808
Effect of Ca²⁺ on the steady-state and time-resolved emission properties of the genetically encoded fluorescent sensor CatchER.
The journal of physical chemistry. B Feb, 2015 | Pubmed ID: 24836743
Enhancing near IR luminescence of thiolate Au nanoclusters by thermo treatments and heterogeneous subcellular distributions.
Nanoscale Jul, 2014 | Pubmed ID: 24879334
Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.
The Journal of biological chemistry Sep, 2014 | Pubmed ID: 25070887
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25143381
Direct determination of multiple ligand interactions with the extracellular domain of the calcium-sensing receptor.
The Journal of biological chemistry Nov, 2014 | Pubmed ID: 25305020
Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.
PloS one , 2014 | Pubmed ID: 25420019
The calcium sensing receptor: from calcium sensing to signaling.
Science China. Life sciences Jan, 2015 | Pubmed ID: 25576451
Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging.
Proceedings of the National Academy of Sciences of the United States of America May, 2015 | Pubmed ID: 25971726
Prostate cancer metastatic to bone has higher expression of the calcium-sensing receptor (CaSR) than primary prostate cancer.
Receptors & clinical investigation , 2014 | Pubmed ID: 26065011
Fast kinetics of calcium signaling and sensor design.
Current opinion in chemical biology Aug, 2015 | Pubmed ID: 26151819
GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.
Scientific reports Nov, 2015 | Pubmed ID: 26577829
Towards the Molecular Imaging of Prostate Cancer Biomarkers Using Protein-based MRI Contrast Agents.
Current protein & peptide science , 2016 | Pubmed ID: 26721404
Prostate-specific membrane antigen targeted protein contrast agents for molecular imaging of prostate cancer by MRI.
Nanoscale Jul, 2016 | Pubmed ID: 26961235
ProCA1.GRPR: a new imaging agent in cancer detection.
Biomarkers in medicine May, 2016 | Pubmed ID: 27071673
Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.
Metallomics : integrated biometal science Jun, 2016 | Pubmed ID: 27108875
Rational design of a protein that binds integrin αvβ3 outside the ligand binding site.
Nature communications May, 2016 | Pubmed ID: 27241473
Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Science advances May, 2016 | Pubmed ID: 27386547
The hills and valleys of calcium signaling.
Science China. Life sciences Aug, 2016 | Pubmed ID: 27502903
Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor.
Frontiers in physiology , 2016 | Pubmed ID: 27746744
Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca(2).
International journal of molecular sciences Mar, 2017 | Pubmed ID: 28335551
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