Jenny J. Yang

Temperature-induced formation of a non-native intermediate state of the all beta-sheet protein CD2.

Structural analysis, identification, and design of calcium-binding sites in proteins.

Isolated EF-loop III of calmodulin in a scaffold protein remains unpaired in solution using pulsed-field-gradient NMR spectroscopy.

Metal-binding studies for a de novo designed calcium-binding protein.

Rational design of a calcium-binding protein.

A grafting approach to obtain site-specific metal-binding properties of EF-hand proteins.

Obtaining site-specific calcium-binding affinities of calmodulin.

Design of a calcium-binding protein with desired structure in a cell adhesion molecule.

Probing site-specific calmodulin calcium and lanthanide affinity by grafting.

Calcium and lanthanide affinity of the EF-loops from the C-terminal domain of calmodulin.

Expression and optical properties of green fluorescent protein expressed in different cellular environments.

The effects of Ca2+ binding on the dynamic properties of a designed Ca2+-binding protein.

ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome.

Amyloid fibril formation by a domain of rat cell adhesion molecule.

Predicting calcium-binding sites in proteins - a graph theory and geometry approach.

Using protein design to dissect the effect of charged residues on metal binding and protein stability.

Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins.

Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47.

Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.

Identification of the calmodulin binding domain of connexin 43.

Developing sensors for real-time measurement of high Ca2+ concentrations.

Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.

Rational design of protein-based MRI contrast agents.

Statistical analysis of structural characteristics of protein Ca2+-binding sites.

Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicity.

Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites.

A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication.

Design, synthesis, and characterization of a calcium-sensitive near infrared dye.

Towards predicting Ca2+-binding sites with different coordination numbers in proteins with atomic resolution.

Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response.

Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells.

Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.

Facilitating chromophore formation of engineered Ca(2+) binding green fluorescent proteins.

Fluorescence complementation via EF-hand interactions.

Viral calciomics: interplays between Ca2+ and virus.

Designing caspase-3 sensors for imaging of apoptosis in living cells.

A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+.

Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins.

Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.

Analysis and prediction of calcium-binding pockets from apo-protein structures exhibiting calcium-induced localized conformational changes.

Protein-based MRI contrast agents for molecular imaging of prostate cancer.

Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.

Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to Production.

Site-specific modification of calmodulin Ca²(+) affinity tunes the skeletal muscle ryanodine receptor activation profile.

Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.

Molecular interaction and functional regulation of connexin50 gap junctions by calmodulin.

HER2 targeted molecular MR imaging using a de novo designed protein contrast agent.

Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments.

PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilities.

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice.

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

Role of calcium in metalloenzymes: effects of calcium removal on the axial ligation geometry and magnetic properties of the catalytic diheme center in MauG.

Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.

Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.

Predicting Ca2+ -binding sites using refined carbon clusters.

Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems.

Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach.

Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis.

Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.

Metal toxicity and opportunistic binding of Pb(2+) in proteins.

Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents.

Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

Gap junction regulation by calmodulin.

Design of ProCAs (protein-based Gd(3+) MRI contrast agents) with high dose efficiency and capability for molecular imaging of cancer biomarkers.

Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.

Effect of Ca²⁺ on the steady-state and time-resolved emission properties of the genetically encoded fluorescent sensor CatchER.

Enhancing near IR luminescence of thiolate Au nanoclusters by thermo treatments and heterogeneous subcellular distributions.

Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.

Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

Direct determination of multiple ligand interactions with the extracellular domain of the calcium-sensing receptor.

Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.

The calcium sensing receptor: from calcium sensing to signaling.

Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging.

Prostate cancer metastatic to bone has higher expression of the calcium-sensing receptor (CaSR) than primary prostate cancer.

Fast kinetics of calcium signaling and sensor design.

GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.

Towards the Molecular Imaging of Prostate Cancer Biomarkers Using Protein-based MRI Contrast Agents.

Prostate-specific membrane antigen targeted protein contrast agents for molecular imaging of prostate cancer by MRI.

ProCA1.GRPR: a new imaging agent in cancer detection.

Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Rational design of a protein that binds integrin αvβ3 outside the ligand binding site.

Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.

The hills and valleys of calcium signaling.

Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor.

Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca(2).