Department of Cardiovascular Surgery,
Graduate School of Medicine,
Department of Cardiovascular Surgery, Graduate School of Medicine
Hidetoshi Masumoto graduated and received his medical degree from Kyoto University, Japan. He completed his Cardiovascular Surgery Residency at Kyoto University Hospital and Kumamoto Central Hospital and joined to Shizuoka City Hospital as a staff surgeon of the Department of Cardiovascular Surgery in 2002.
Besides his clinical career, Hidetoshi Masumoto started his research career from 2007 at the Department of Cardiovascular Surgery and Center for iPS Cell Research and Application (CiRA), Kyoto University and received a doctorate in medicine in 2012 for the researches about cardiac regeneration based on pluripotent stem cells and cell sheet technology. In 2013, he moved to Cardiovascular Innovation Institute, University of Louisville, Kentucky, USA as a postdoctoral fellow to expand his research for the clinical translation of biomimetic artificial heart tissues including human induced pluripotent stem (iPS) cell-derived cardiovascular cell lineages. In 2015, he returned to Kyoto University as an Assistant Professor at CiRA then moved to the Department of Cardiovascular Surgery, Kyoto University Hospital in 2016. In 2017, Hidetoshi Masumoto launched an independent research group as the Leader for Clinical Translational Research Program at RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan in addition with the clinical position at Kyoto University Hospital.
Hidetoshi Masumoto’s research focuses on clinical translation of human iPS cell technology in cardiovascular medicine including cardiac regenerative therapy, disease modeling and drug discovery using bioengineered human iPS cell-derived cardiac tissues, development of the strategies for the improvement of the outcome of cardiovascular surgery using various animal disease models.
Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization.
Stem cells (Dayton, Ohio) Jun, 2012 | Pubmed ID: 22438013
Cardiovascular surgery for realization of regenerative medicine.
General thoracic and cardiovascular surgery Nov, 2012 | Pubmed ID: 22933086
Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives.
The Journal of thoracic and cardiovascular surgery Nov, 2013 | Pubmed ID: 23582278
Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin.
Interactive cardiovascular and thoracic surgery Mar, 2014 | Pubmed ID: 24327573
Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype.
The Journal of thoracic and cardiovascular surgery Aug, 2014 | Pubmed ID: 24507892
Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.
Scientific reports Oct, 2014 | Pubmed ID: 25336194
Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells.
Scientific reports Nov, 2015 | Pubmed ID: 26585309
Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass.
The Annals of thoracic surgery Apr, 2016 | Pubmed ID: 26675556
The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages.
Scientific reports Jul, 2016 | Pubmed ID: 27435115
Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model.
Journal of vascular surgery Jun, 2017 | Pubmed ID: 27473778
Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration.
Current treatment options in cardiovascular medicine Nov, 2016 | Pubmed ID: 27637492
Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model.
The Journal of thoracic and cardiovascular surgery Mar, 2017 | Pubmed ID: 27838010
Untiring steps toward the maturation of human stem cell-engineered heart tissue.
Annals of translational medicine Feb, 2017 | Pubmed ID: 28275632
Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.
PloS one , 2017 | Pubmed ID: 28288160
Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
Scientific reports Apr, 2017 | Pubmed ID: 28368043
Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model.
The Journal of thoracic and cardiovascular surgery Dec, 2017 | Pubmed ID: 28645823
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue.
Nature communications Oct, 2017 | Pubmed ID: 29057872
Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.
Journal of vascular surgery Dec, 2017 | Pubmed ID: 29242072
Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82.
Cell reports Jan, 2018 | Pubmed ID: 29320747
A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model.
Heart and vessels Oct, 2018 | Pubmed ID: 29761379
Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.
General thoracic and cardiovascular surgery Nov, 2018 | Pubmed ID: 29982930
Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.
PloS one , 2018 | Pubmed ID: 30071102
Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.
Inflammation and regeneration , 2018 | Pubmed ID: 30338009
MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.
The Journal of thoracic and cardiovascular surgery 06, 2019 | Pubmed ID: 30447962
Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues.
Journal of tissue engineering Jan-Dec, 2019 | Pubmed ID: 31024681
Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model.
General thoracic and cardiovascular surgery Apr, 2020 | Pubmed ID: 31410725
The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model.
General thoracic and cardiovascular surgery Jan, 2020 | Pubmed ID: 31955320
Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (L-lysine)-based biocompatible glue.
General thoracic and cardiovascular surgery Jan, 2020 | Pubmed ID: 31981138
Takeichiro Nakane1,2,6,
Mosha Abulaiti1,2,
Yuko Sasaki1,
William J. Kowalski3,
Bradley B. Keller4,5,7,
Hidetoshi Masumoto1,2
1Clinical Translational Research Program, RIKEN Center for Biosystems Dynamics Research,
2Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University,
3Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Institutes of Health,
4Kosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville,
5Department of Pediatrics, School of Medicine, University of Louisville,
6Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital,
7, Cincinnati Children's Heart Institute
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