Rudi D'Hooge

Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.

Sex differences in human virtual water maze performance: novel measures reveal the relative contribution of directional responding and spatial knowledge.

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin.

Stimulus generalization and return of fear in C57BL/6J mice.

Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice.

Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice.

Homologous involvement of striatum and prefrontal cortex in rodent and human water maze learning.

Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.

Selective inhibition of phosphodiesterase 10A impairs appetitive and aversive conditioning and incentive salience attribution.

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.

More complex brains are not always better: rats outperform humans in implicit category-based generalization by implementing a similarity-based strategy.

Distinct and simultaneously active plasticity mechanisms in mouse hippocampus during different phases of Morris water maze training.

MMP-2 mediates Purkinje cell morphogenesis and spine development in the mouse cerebellum.

Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability.

SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice.

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.

Virtual water maze learning in human increases functional connectivity between posterior hippocampus and dorsal caudate.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Functional Dissociation of Group III Metabotropic Glutamate Receptors Revealed by Direct Comparison between the Behavioral Profiles of Knockout Mouse Lines.

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Feature- versus rule-based generalization in rats, pigeons and humans.

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice.

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum.

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition.

The elusive nature of the blocking effect: 15 failures to replicate.

MS imaging and mass spectrometric synaptosome profiling identify PEP-19/pcp4 as a synaptic molecule involved in spatial learning in mice.

Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity.

Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice.

Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.

Individual Difference Factors in the Learning and Transfer of Patterning Discriminations.

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition.

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains.

Prevention and treatment strategies for contextual overgeneralization.

Testosterone boosts physical activity in male mice via dopaminergic pathways.