Katalin Kariko

Extracellular mRNA induces dendritic cell activation by stimulating tumor necrosis factor-alpha secretion and signaling through a nucleotide receptor.

Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface.

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference.

mRNA is an endogenous ligand for Toll-like receptor 3.

Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells.

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes.

Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

Induction of tolerance to focal ischemia in rat brain: dissociation between cortical lesioning and spreading depression.

Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance.

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

Cerebral preconditioning using cortical application of hypertonic salt solutions: upregulation of mRNAs encoding inhibitors of inflammation.

gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission.

Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation.

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage.

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.

Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage.

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin.